Natural Product Chemistry and Process Development
Senior Scientist
Medicinal Chemistry, Diversity-Oriented Synthesis & Chemical Biology, Natural Product Synthesis

Medicinal Chemistry Our research interests are primarily in the design and synthesis of novel drug targets with a particular focus on natural products analogue for the treatment of inflammation, Cancer and Microbial-infections. Diversity Oriented Synthesis and Chemical Biology The ability of small molecules to interact with a specific gene product or a protein and perturb their function has emerged as a powerful tool for the studying biological processes and forms the basis of modern medicine. We are interested in developing novel methodologies for the synthesis of skeletally diverse small molecule libraries of therapeutic importance. Natural Product Synthesis Natural products have been source of inspiration for the discovery of many drug substances. Likewise, in our quest to understand the function of molecules, we work on the development of new methods and routes for the synthesis of complex molecules possessing interesting structural, biological, and physical properties. Ultimately, we will have access to important biologically active compounds prepared through novel and efficient routes, as well as new techniques for the preparation of other structurally unique targets. Particular natural products of focus include targets with relevance to cancer chemotherapy and inflammation. Publications: “Synthesis of skeletally-diverse alkaloid-like molecules: Exploitation of metathesis substrates assembled from triplets of building blocks� Sushil K. Maurya, Mark Dow, Stuart Warriner and Adam Nelson, Beilstein J. Org. Chem. 9,(2013),775–785. "Synthesis of Skeletally-Diverse Alkaloid-like Small Molecules " Sarah Murrison, Sushil K. Maurya, Christian Einzinger, Ben McKeever-Abbas, Stuart Warriner and Adam Nelson, Eur. J. Org. Chem. (2011) 2354–2359. "A screening pipeline for antiparasitic agents targeting Cryptosporidium inosine monophosphate dehydrogenase" Lisa Sharling, Xiaoping Liu, Deviprasad R. Gollapalli, Sushil K. Maurya, Lizbeth Hedstrom and Boris Striepen, PLoS Neglected Tropical Diseases 4 (8), (2010), e794. "Triazole Inhibitors of Cryptosporidium parvum Inosine 5'-Monophosphate Dehydrogenase" Sushil K. Maurya, Deviprasad R. Gollapalli, Shivapriya Kirubakaran, Minjia Zhang, Corey R. Johnson, Nicole K. Benjamin, Lizbeth Hedstrom and Gregory D. Cuny, J. Med. Chem. 52, (2009) 4623-4630. Patents: “Compounds and methods for treating mammalian gastrointestinal microbial infections� Lizbeth K. Hedstrom, Gregory D. Cuny, Deviprasad R. Gollapalli, Sivapriya Kirubakaran, Sushil K. Maurya, Boris Striepen, Suresh K. Gorla, Corey R. Johnson, Mandapati Kavitha, Jihan Khan; US 2015/0099781. “1,6-Diazabicyclo[3,2,1]octan-7-one derivatives and their use in the treatment of Bacterial Infections� Patil, V. J.; Tadiparthi R.; Dond, B.; Kale, A.; Velupillai, L.; Dekhane, D.; Birajdar, S. S.; Shaikh, M. U.; Maurya, Sushil K., Patel, P. A.; Dixit, P.; Pawar, M.; Patel, M. V.; Bhagwat, S.; WO 2014/033560. “Compounds and methods for treating mammalian gastrointestinal microbial infections� Lizbeth K Hedstrom, Gregory D Cuny, Deviprasad R Gollapalli, Sivapriya Kirubakaran, Sushil Kumar Maurya, Boris Striepen, Suresh Kumar Gorla, Corey Robert Johnson, Mandapati Kavitha, Jihan Khan; US 2012/0101096. “Compounds and methods for treating mammalian gastrointestinal microbial infections� Lizbeth K Hedstrom, Gregory D Cuny, Deviprasad R Gollapalli, Sivapriya Kirubakaran, Boris Striepen, Suresh Kumar Gorla, Sushil K. Maurya, Corey Robert Johnson, Mandapati Kavitha, Jihan Khan; EP 2012/2408753. “Compounds and methods for Treating Mammalian Gastrointestinal Microbial Infections� Hedstrom, Lizbeth, K.; Cuny, Gregory, D.; Gollapalli, Deviprasad, R.; Kirubakaran, Sivapriya; Striepen, Boris; Gorla, Suresh Kumar; Maurya, Sushil K.; Johnson, Corey Robert; Kavitha, Mandapati; Khan, Jihan; WO 2010/108187 PCT/US 2010/028178. “Triazoles to treat cryptosporidiosis� Hedstrom L, Maurya S, Gollapalli D, Cuny G, Sharling L, Striepen B, Kirubkaran S Provisional Patent No. 61/162,013, 2009.

2008-2010: Marie Curie International Incoming Fellowship, University of Leeds, UK 2007-2008: Postdoctoral Fellowship, Brigham and Women’s Hospital, Harvard Medical School and Brandeis University, USA 2003-2004: Visiting Scientist Fellowship, Humboldt University, Germany 2002-2007: UGC-Junior and Senior Research Fellowship, NCL-Pune, India 2001-2002: Junior Research Fellowship, CIMAP-Lucknow, India

Talented and highly motivated candidates with their own fellowship interested in doing research in medicinal chemistry, natural product synthesis and chemical biology are welcome to apply. Candidates interested in applying for their own postdoctoral/ Ph.D funding should contact with detailed CV and research interest.

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