Natural Product Chemistry and Process Development
Catalysis; C-H Activation; Natural Product Chemistry; Analytical Chemistry
01894 230426, Ext. 449; Mob. 09418792595


Organic Synthesis & Catalysis

Transition Metal Catalysis for C-H Activation/Functionalization

Medicinal Chemistry

Synthesis of New Heterocycles (Quinoline, Indole, Furan) Derivatives as Potential Therapeutic Agents

Natural Product Chemistry

Characterization of New Molecules from Western Himalayan Plants

Chemical Profiling of Medicinal Plants

Scientific Validation of Traditional Knowledge on Himalayan Plants

Cellulose Prospection from Underutilized Himalayan Bioresurce for Valuable Products



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Selected Publications


Organic Synthesis, Catalysis & Medicinal Chemistry

98. Rh(III)-Catalyzed C(8)-H Activation of Quinoline N-oxides: Regioselective C-Br and C-N Bond Formation.

A. K. Dhiman, S. S. Gupta, R. Sharma, R. Kumar and U. Sharma*

The Journal of Organic Chemistry, 2019, [Link]


97. Catalyst-Free Synthesis of 2-Anilinoquinolines and 3-Hydroxyquinolines via Three-Component Reaction of Quinoline N-oxides, Aryldiazonium salts and Acetonitrile.

A. K. Dhiman, D. Chandra, R. Kumar and U. Sharma*

The Journal of Organic Chemistry, 2019, 84, 6962. [Link]


96. Microwave-Assisted Metal-Free Rapid Synthesis of C4-Arylated Quinolines via Povarov Type Multicomponent Reaction.

D. Chandra, A. K. Dhiman, R. Kumar and U. Sharma*

European Journal of Organic Chemistry, 2019, 2019, 2753. [Link]


95. Rh/O2-Catalyzed C8 Olefination of Quinoline N-oxides with Activated and Unactivated Olefins.

R. Sharma, R. Kumar and U. Sharma*

The Journal of Organic Chemistry, 2019, 84, 2786. [Link]


94. Cp*Co(III)- Alkylation of Primary and Secondary C(sp3)-H Bonds of 8-Methylquinolines with Maleimides.

R. Kumar, R. Kumar, D. Chandra and U. Sharma*

The Journal of Organic Chemistry, 2019, 84, 1542. [Link]


93. Rh(III)-Catalyzed C(8)-H Functionalization of Quinolines via Simultaneous C-C and C-O Bond Formation: Direct Synthesis of Quinoline Derivatives with Antiplasmodial Potential.

R. Sharma, R. Kumar, R. Kumar, P. Upadhyay, D. Sahal and U. Sharma*

The Journal of Organic Chemistry, 2018, 83, 12710. [Link]


92. A Catalyst and Additive-free Diastereoselective 1,3-Dipolar Cycloaddition of Quinolinium Imides with Olefins, Maleimides and Benzynes: Direct Access to Fused N,N´-Heterocycles with Promising  Activity against Drug Resistant Malaria Parasite.

R. Kumar, S. Chaudhary,  R. Kumar, P. Upadhyay, D. Sahal and U. Sharma*

The Journal of Organic Chemistry, 2018, 83, 11570. [Link] 


91. Remote C-H Bond Activation/Transformations: A Continuous Growing Synthetic Tool; Part II.

R. Sharma, and U. Sharma*

Catalysis Reviews: Science and Engineering, 2018, 60, 497. [Link].


90. C70 Fullerene-Catalyzed Metal-Free Photocatalytic ipso-Hydroxylation of Aryl Boronic Acids: Synthesis of Phenols 

I. Kumar, R. Sharma, R. Kumar, R. Kumar and U. Sharma*

Advanced Synthesis & Catalysis, 2018, 360, 2013. [Link]


89. Rhodium-Catalyzed Remote (C-8) alkylation of Quinolines with Activated and Unactivated Olefins: Mechanistic Study and Total Synthesis of EP4 Agonist 

R. Sharma, I. Kumar, R. Kumar and U. Sharma*

Advanced Synthesis & Catalysis, 2017, 359, 3022. [Link]


88. Metal-free synthesis of 2-substituted-3-(2-hydroxyaryl)quinolines and 4-(2-hydroxyaryl)acridines via benzyne chemistry

A. K. Dhiman, R. Kumar, R. Kumar,* and U. Sharma*

The Journal of Organic Chemistry, 2017, 82, 12307. [Link]


87. Regioselective Metal-free C(2)-H Arylation of Quinoline N-oxides with Aryldiazonium Salts/Anilines under Ambient Conditions.

R. Kumar, R. Kumar, A. K. Dhiman and U. Sharma*

Asian Journal of Organic Chemistry, 2017, 6, 1043. [Link] 


86. CuI nanoparticles as a recyclable heterogeneous catalyst for C-N bond formation reactions.

M. Kumar, V. Bhatt, O. S. Nayal, S. Sharma, V. Kumar, M. S. Thakur, N. Kumar, R. Bal,* B. Singh* and U. Sharma*

Catalysis Science & Technology, 2017, 7,  2857. [Link]


85. Synthesis of tertiary arylamines: Lewis acid-catalyzed direct reductive N-  alkylation of secondary amines with ketones through an alternative pathway.

O. S. Nayal, M. S. Thakur, V. Bhatt, M. Kumar, N. Kumar, B. Singh* and U. Sharma*

Chemical Communications, 2016, 52, 9648. [Link]


84. Catalyst and Solvent-Free alkylation of Quinoline N-oxides with Olefins: Direct Access to Quinoline Substituted α–Hydroxy Carboxylic Derivatives.

R. Kumar, I. Kumar, R. Sharma and U. Sharma*

Organic & Biomolecular Chemistry, 2016, 14, 2613. [Link]


83. Rh(III)-Catalyzed Dehydrogenative Coupling of Quinoline N-Oxides with Alkenes: N-Oxide as Traceless Directing Group for Remote C-H Activation.

R. Sharma, R. Kumar, I. Kumar and U. Sharma*

European Journal of Organic Chemistry, 2015, 7519. [Link]


82. Distant C-H Activation/Functionalization: A New Horizon of Selectivity beyond Proximity. 

R. Sharma, K. Thakur, R. Kumar, I. Kumar and U. Sharma*

Catalysis Reviews: Science and Engineering, 2015, 57(3), 345. [Link]


81. Orthogonal Selectivity with Cinnamic Acids in 3-Substituted Benzofuran Synthesis through C-H Olefination of Phenols.

S. Agasti, U. Sharma, T. Naveen and D. Maiti

Chemical Communications2015, 51, 5375.


80. Palladium-Catalyzed Annulation of Diarylamines with Olefins through C-H Activation: Direct Access to N-Arylindoles.

U. Sharma, R. Kancherla, N. Tagoti, S. Agasti amd D. Maiti

Angewandte Chemie International Edition, 2014, 53, 43.


79. Rh (III)- Catalyzed Traceless Coupling of Quinoline N-Oxides with Internal Diarylalkynes.

U. Sharma, Y. Park and S. Chang

Journal of Organic Chemistry, 2014, 79, 9899.


78. Palladium Ctalyzed Synthesis of Benzofurans and Coumarins from Phenols and Olefins.

U. Sharma, N. Tagoti, A. Maji, S. Manna and D. Maiti 

Angewandte Chemie International Edition, 2013, 52, 12669.


Natural Product Chemistry (Plants)


77. Simultaneous Quatification and Idetification of Amaryllidaceae Alakloids in Narcissus tazetta by Ultra Performance Liquid Chromatography-Diode Array Detector-Electrospray Ionisation Tandem Mass Spectrometry.

D. Katoch* and U. Sharma*

Journal of Pharamaceuticaland Biomedical Analysis, 2019, [Link]


76. Pseudolycorine N-oxide, a new N-oxide from from Narcissus tazetta.

D. Katoch,* D. Kumar, Y. S. Padwad, B. Singh,* and U. Sharma*

Natural Product Research, 2019, [Link]


75. Narciclasine-4-O-β-D-xylopyranoside, a new narciclasine glycoside from Zephyranthes minuta.

D. Katoch,* D. Kumar, Y. S. Padwad, B. Singh,* and U. Sharma*

Natural Product Research, 2019, [Link]


74. Comprehensive metabolomics study of traditionally Important Rumex Species found in Western Himalayan region.

R. Sharma, R. Jandrotia, B. Singh, U. Sharma* and D. Kumar*

Natural Product Communications, 2018, 13, 189.


73. Comprehensive metabolic profiling of Zanthoxylum armatum and Zanthoxylum acanthopodium leaves, bark, flowers and fruits using Ultra high performance liquid chromatography.

V. Bhatt, N. Kumar, U. Sharma and B. Singh*

Separation Science Plus, 2018, 1, 311-324. [Link]


72. Simultaneous quantification and identification of flavonoids, lignans, coumarin and amides in leaves of Zanthoxylum armatum using UPLC-DAD-ESI-QTOF–MS/MS.

V. Bhatt, S. Sharma, N. Kumar, U. Sharma and B. Singh

Journal of Pharmaceutical and Biomedical Analysis, 2017, 132, 46. [Link]


71. Cuspidate A, New Anti-Fungal Triterpenoid Saponin from Lepidagathis cuspidate

R. Rattan,* B. I. Fozdar, V. Gautam, R. Sharma,  D. Kumar* and U. Sharma


Natural Product Research, 2017, 31, 773. [Link]


70. Triterpenoid Saponins from Clematis graveolens and Evaluation of their Insecticidal Activities.

R. Rattan*, S. G. E. Reddy, S. K. Dolma, B. I. Fozdar, V. Gautam, R. Sharma and U. Sharma*

Natural Product Communications, 2015, 10(9), 1525.


69. Immunomodulatory Active Compounds from Tinospora cordifolia.

U. Sharma, M. Bala, N. Kumar, R. Munshi, S. Bhalerao and B. Singh

Journal of Ethnopharmacology, 2012, 141, 918.


68. New Furostanol Saponin and Phenyl Propanoid from Roots of Asparagus racemosus.

U. Sharma, N. Kumar, and B. Singh

Natural Product Communications2012, 7, 995.


Full List and Details: Complete Publications Details



Manjushree Pal Memorial Award for Best Oral Presentation from Ethanopharmacology Society of India, Kolkata (2017)

Thieme Chemistry Journal Award (2016)

Postdoc Fellowship KAIST, South Korea (2014)

D S Kothari Postdoc Fellowship (2012)

Fast Track Young Scientist project for three years (2012)

CSIR Senior Research Fellowship (2009)

CSIR Junior Research Fellowship (2007)

GATE (2007)

CSIR-NET (2006) 

Book Chapters

4. Direct Arylation via C-H activation.

U. Sharma, A. Modak, S. Maity, A. Maji and D. Maiti

Thomas CoIacot eds., Introduction to New Trends in Cross-Coupling: Theory and   

Applications. 2014. [Link]


3. In Vitro Studies on the Antioxidant/Antigenotoxic Potential of Aqueous Fraction from Anthocephalus cadamba Bark.

M. Chandel, U. Sharma, N. Kumar, B. Singh and S. Kaur

P. R. Sudhakaran et. al. (eds.), Perspectives in Cancer Prevention-Translational Cancer Reserch, 2013, pp 61-72. [Link]



2. Benzothiazole Substituted Phthalimide Analogues as Potential Angiogenesis Inhibitors.

B. Singh, S. Chattergi, N. Kumar and U. Sharma.  

Ref. No. 0918 DEL 2011.


1. Palladium-Catalyzed Synthesis of Benzofurans and Coumarins from Phenols and Olefins.

U. Sharma, N. Tagoti, and D. Maiti.  

Status: Provisional. IPA No: 2012/Mum/2013.





Dr. Vinod Bhatt

Dr. Vishal Priya 


Ph.D Fellow

Mr. Rakesh Kumar

Mr. Inder Kumar

Mr. Ankit K Dhiman

Mr. Patil Shivprasad Suresh

Mr. Devesh Chandra

Ms. Diksha Parmar

Ms. Surekha Kumari



Project Fellow

Mr. Prateek Singh Bora

Mr. Rohit Kumar

Mr. Prithvi Pal Singh

Ms. Shivani Puri

Mr. Shiv Sankar Gupta


Thesis Awarded

Dr. Vinod Bhatt, Feb. 2018

Dr. Deepali Katoch, July 2019  

Dr. Ritika Sharma, July 2019 


Past Team Members 

Ms. Divya Rana, PA-II, 2018-2019

Dr. Ashun Chaudhary, Postdoc, 2016-2018

Dr. Rakesh Kumar, Postdoc, 2016-2017



Prospective Team Members 

Ph.D and Postdoc positions available for self-motivated persons.





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