Group Website: CH Activation & Phytochemistry

Organic Synthesis & Catalysis

   C-H Activation/functionalization

   Atropselective C-H Activation/Functionalization

   Photocatalysis

   Heterocycles Synthesis 

Phytochemistry (Himalayan Medicinal Plants)

    Isolation and structure elucidation of  plant secondary metabolites

    Standardization of plant extracts (targetted activity & four marker compounds) 

    Development of analytical methods (UPLC, GC, and NMR) 

    Chemical profiling using NMR (1D & 2D), UPLC-MS/MS, and GC-MS/MS

    Bio(Chemomatrcis)-based generation of plant authentication database

    NADES-based extraction/enrichment of plant products

Medicinal Chemistry 

    Discovery of new heterocycles as potential therapeutic agents 

    Scientific validation of plant traditional knowledge (Ayush or Phytopharma route)

Funding 

      Project Completed: 17 (PI: 06;  Co-PI: 11); External Funded: 03

      Project Ongoing: 10 (PI: 04;  Co-PI: 06); External Funded: 06

Selected Publications in the last three years

Organic Synthesis and Catalysis 

197. Trends in Chemistry, 2024, accepted.

196. Organic Letters, 2024, doi.org/10.1021/acs.orglett4c03096. [Link]

195. Journal of Catalysis,  2024, 115756. [Link]

194. The Journal of Organic Chemistry, 2024, doi.org/10.1021/acs.joc.4c01650. [Link]

193. Journal of Catalysis, 2024  438,  115673.[Link]

192. Organic Chemistry Frontiers,  2024, 11, 4986.  [Link]

191. Molecular Catalysis, 2024, 568, 114395. [Link]

190. Organic Letters,  2024, 26, 5027. [Link]

189. Trends in Chemistry,  2024, 6, 277. [Link]

188. Coordination Chemistry Reviews,  2024, 499, 215453. [Link]

187.  Chemical Communications, 2024, 60, 5626. [Link]

186.  Molecular Catalysis, 2023, 551, 113597. [Link]

185. Chemical Communications,  2023,  59, 9646. [Link]

184. Chemistry A European Journal, 2023  e202301360. [Link] [Published as Hot Article]

183. Chemical Communications, 2023, 59, 9288. [Link] 

182. Organic Letters, 2023, 25, 2627. [Link]

181. The Journal of Organic Chemistry, 2023, 88,  2314. [Link]  

180. Chem. Commun.,  2022 58, 13151. [Link] [Invited for Emerging Investigators Series]

179. Advanced Synthesis & Catalysis, 2022, 364, 897. [Link]

178. Catalysis Reviews, 2022, 64, 716. [Link]

177. The Chemical Records, 2022, 22, e202100271. [Link]

Phytochemistry 

176. Separation and Purification Technology, 2024, 354, 128699. [Link]

175. Fitoterapia, 2024, 17, 105925. [Link]

174. Phytochemical Analysis, 2024, 35, 1265. [Link]

173. Microchemical Journal, 2024, 205, 111210. [Link] 

172. Microchemical Journal, 2024, 199, 110129. [Link]

171. Natural Product Research, 2024, DOI.org/1080/14786419.2024.2375318. [Link]

170. Natural Product Research,  2024, DOI:10.1080/14786419.2024.2326979.  [Link]

169. Journal of Ethnopharmacology, 2024, 320, 117385. [Link]

168. Natural Product Research, 2024, 38,  440. [Link]

167. European Journal of Medicinal Chemistry, 2023, 115748. [Link]

166. Sustainable Chemistry and Pharmacy, 2023, 36, 101305. [Link]

165. Steroids, 2023, 199, 109293. [Link]

164. Journal of Molecular Structure, 2023, 1292, 136077. [Link]

163. Industrial Crops and Products,  2023, 202, 117040. [Link]

162. Journal of Ethnopharmacology,  2023, 310, 116389. [Link]

161. Food Research International,  2023, 164, 112434. [Link]

160.  Journal of Cleaner Production, 2023, 385,  135639. [Link]

159. Biomass Conversion and Biorefinery, 2023, 13, 311. [Link]

158. Separation and Purification Technology, 2022, 294, 121105. [Link]

Complete List of  Publications

Fellow of Royal Society of Chemistry(FRSC), London, UK (2023-)

Member, Editorial Board, Scientific Reports (2024-). [Link]

Member, Early Career Board, Science of Synthesis (2022-). [Link]

Member, Early Career Advisory Board, Asian Journal of Organic Chemistry (2020-). [Link]

One Year Advance Promotion i.e., Merit Promotion from Scientist to Senior Scientist.

Manjushree Pal Memorial Award for Best Oral Presentation from Ethanopharmacology Society of India, Kolkata (2017)

Thieme Chemistry Journal Award (2016)

Postdoc Fellowship KAIST, South Korea (2014)

D S Kothari Postdoc Fellowship (2012)

Fast Track Young Scientist project for three years (2012)

CSIR Senior Research Fellowship (2009)

CSIR-Junior Research Fellowship (2007)

GATE (2007)

CSIR-NET (2006) 

Book Edited 

Functionalization of Heterocycles through Transition Metal Catalyzed C-H Activation. 

Editors:  Debabrata Maiti & Upendra Sharma, 

Topic in Heterocyclic Chemistry (Springer).

2024, Vol. 60, doi.org/10.1007/978-3-031-70843-5. [Link]                                                                

Book Chapters

12. 15.3.5 Synthesis of Quinoline Derivatives by Modification of Methyl Substituents at the C2 or C8 Position. 

U. Sharma,* D. Parmar, Sumit, and Manisha

Science of Synthesis Knowledge Update  (Thieme), 2024,  15, 1-200. [Link]

11. Plant-based natural product chemistry: An overview of the multistep journey involved in scientific validation of traditional knowledge.

Anmol, G. Aggarwal, M. Sharma, R. Singh, Shivani, and U. Sharma*

Studies in Natural Product Chemistry (Elsevier), 2024, 80, 327-277. [Link]

10. Quinolines (Update 2022)  

U. Sharma,* R. Kumar, S. S. Gupta, D. Chandra. 

Science of Synthesis Knowledge Updates  (Thieme), 2022, 2, 63-327. [Link]

9. Integrated Approach for the Quality Assurance of Commercially Important Himalayan Medicinal Plants.

 P. S. Bora, P. S. Suresh, S. Kumari, Anmol, S. Puri, and U. Sharma.* 

Ekiert H. M., Ramawat K. G., Arora J. (eds)  

Medicinal Plants. Sustainable Development and Biodiversity (Springer), 2021, 28, 721-768. [Link]

8. Steroidal Sapogenins from Genus Trillium: Chemistry, Synthesis, and Opportunities in Neuro-active Steroids Designing. 

P. S. Suresh, V. Bhatt, P. P. Singh, and U. Sharma.*

Studies in Natural Product Chemistry (Elsevier), 2021, 68, 67-95. [Link] 

7. Direct Arylation via C-H activation.

U. Sharma, A. Modak, S. Maity, A. Maji, and D. Maiti.*

Thomas CoIacot eds., Introduction to New Trends in Cross-Coupling: Theory and   

Applications (RSC), 2014. [Link]

Complete List of Book Chapters

3. An Eco-friendly Process for Isolation of Fiber from Plant Species and Product thereof. 

M. Sharma, S. Thakur, U. Sharma, and S. Kumar. 

Ref. No. 202011034404. Date of Filing: 11-08-2020.  

2. Palladium-Catalyzed Synthesis of Benzofurans and Coumarins from Phenols and Olefins.

D. Maiti, U. Sharma, and N. Tagoti.  

Indian Patent No. 299110; Date of Grant: 24-07-2018.

1. Benzothiazole Substituted Phthalimide Analogues as Potential Angiogenesis Inhibitors.

B. Singh, S. Chattergi, N. Kumar and U. Sharma.  

Indian Patent No. 318680; Date of Grant: 22-08-2019.

Postdoc Fellow

Dr. Devesh Chandra

Dr. Arif Khan

Ph.D. Fellows

Ms. Shivani Puri

Ms. Shivani

Mr. Raman Singh

Ms. Mehak Sharma

Mr. Prateek Singh Bora

Mr. Gaurav Aggrawal

Mr. Sachin

Project Fellows

Mr. Sarthi

Ms. Tamanna Sharma

Mr. Shourabh Rav

Mr. Aadarsh Shrivastav

Mr. Aryan Bhardwaj

Ms. Reetika Sharma

Group Alumni 

Ph.D. Thesis Submitted

Ms. Ankita Thakur, September 2024.

Mr. Sumit, September 2024. 

Ms. Manisha, September 2024.

Mr. Shiv Shankar Gupta, September 2024.

Mr. Anmol, August 2024.

Ph.D. Thesis Awarded 

Dr. Prithvi Pal Singh, September 2024. [Parastoo Azadi Group, University of Georgia, USA]

Dr. Rohit Kumar, April 2024. [Jiang Research Group, Wayne State University, USA]

Dr. Devesh Chandra, March 2024.

Dr. Diksha Parmar, March 2024.

Dr. Surekha Kumari, February 2024.

Dr. Patil Shivprasad Suresh, February 2022. [Zhang Research Group, UNC, USA]

Dr. Ankit K Dhiman, December 2021. [Stepien Group, University of Wroclaw, Poland]

Dr. Inder Kumar, July 2021, Current Position: Asst. Prof. at Govt. Degree College (HPU) 

Dr. Rakesh Kumar, February 2020. [Olofsson Group, Stockholm University, Sweden]

Dr. Ritika Sharma, July 2019. [Prof. D. S. Rawat Group, Delhi University, India]

Dr. Deepali Katoch, July 2019 

Dr. Vinod Bhatt, February 2018

Postdocs

Dr. Manish Kumar Gupta, SPA, 2022-2023; Current Position: Postdoc at IIT Roorkee.

Dr. Vinod Bhatt, RA, 2018-2019.

Dr. Ashun Chaudhary, Postdoc, 2016-2018; Current Position: Asst. Prof. at CUHP.

Dr. Rakesh Kumar, Postdoc, 2016-2017; Current Position: Asst. Prof. at NIT Jalandhar.

Project Fellows and Trainees

25 Project Assistants and 29 Trainees worked in the lab.

Prospective Team Members

Two Ph.D. Positions are available for JRF candidates in the C-H activation area.

Postdoc Positions are Available for Self-Motivated Persons.