Natural Product Chemistry and Process Development
Senior Scientist
Medicinal Chemistry, Natural Product Synthesis, Synthetic Organic & Catalysis Chemistry, Chemical Biology
+91-8628045076
Ph. D.
CV.pdf

Medicinal Chemistry: Our research interests are primarily in the design and synthesis of novel drug targets with a particular focus on natural products analogue for the treatment of Microbial-infections.

Natural Product Synthesis: Natural products have been source of inspiration for the discovery of many drug substances. Likewise, in our quest to understand the function of molecules, we work on the development of new methods and routes for the synthesis of complex molecules possessing interesting structural, biological, and physical properties. Ultimately, we will have access to important biologically active compounds prepared through novel and efficient routes, as well as new techniques for the preparation of other structurally unique targets. Particular natural products of focus include targets with relevance to antimicrobial-infections and cancer chemotherapy.

Synthetic Organic & Catalysis Chemistry: Avoiding the implication of hazardous solvents, toxic metals and using environmentally benign solvents in the organic transformations is an important and promising alternatives for modern chemistry. We are interested in developing catalyst for various organic transformation and their applications in the synthesis of value added products utilizing natural resources.

Chemical Biology: The ability of small molecules to interact with a specific gene product or a protein and perturb their function has emerged as a powerful tool for the studying biological processes and forms the basis of modern medicine. We are interested in developing novel methodologies for the synthesis of skeletally diverse small molecule libraries of therapeutic importance.

2008-2010: Marie Curie International Incoming Fellowship, University of Leeds, Leeds, UK

2007-2008: Postdoctoral Fellowship, Harvard Medical School and Brandeis University, Boston, USA

2003-2004: Visiting Scientist Fellowship, Humboldt University, Berlin, Germany

2002-2007: Junior and Senior Research Fellowship, CSIR-NCL, Pune, India

2001-2002: Junior Research Fellowship, CSIR-CIMAP, Lucknow, India

“Tridecaptin M, a new variant discovered in mud bacterium shows activity against colistin- and extremely drug-resistant Enterobacteriaceae” Manoj Jangra, Manpreet Kaur, Rushikesh Tambat, Rohit Rana, Sushil K. Maurya, Neeraj Khatri, Abdul Gafur and Hemraj Nandanwar Antimicrobial Agents and Chemotherapy, DOI: 10.1128/AAC.00338-19.  

“Tin(II) triflate catalysed synthesis of 3-Methyleneisoindolin-1-ones” Simmi Sharma, Onkar S. Nayal, Arti Sharma, Rohit Rana and Sushil K. Maurya* ChemistrySelect 4, (2019), 1985-1988. 

“Lewis acid catalyzed direct nucleophilic substitution reaction of alcohols for the functionalization of aromatic amines” Onkar S. Nayal, Maheshwar S. Thakur, Rohit Rana, Rahul Upadhyay, and Sushil K. Maurya* ChemistrySelect, 4, (2019), 1371-1374.

 “An Efficient Metal‐Free Mono N‐Alkylation of Anilines via Reductive Amination using Hydrosilanes” Maheshwar S. Thakur, Onkar S. Nayal, Rohit Rana, Arti Sharma, Neeraj Kumar and Sushil K. Maurya* Eur. J. Org. Chem. (2018), 6729-6732.

“Insecticidal activity and structure–activity relationship of sugar embedded macrocycles for the control of aphid (Aphis craccivora Koch)” Rohit Rana, Shudh Kirti Dolma, Sushil K. Maurya* & S. G. Eswara Reddy* Toxin Reviews https://doi.org/10.1080/15569543.2018.1498897

“2-Aminoquinazolin-4(3H)-one as an organocatalyst for the synthesis of tertiary amines” Maheshwar S. Thakur, Onkar S. Nayal, Rahul Upadhyay, Neeraj Kumar and Sushil K. Maurya* Org. Lett. 20, (2018),1359-1362.

“Sustainable and efficient CuI-NPs-Catalyzed cross-coupling approach for the synthesis of tertiary-3-aminopropenoates, triazoles and ciprofloxacin” Onkar S. Nayal, Maheshwar S. Thakur, Manoranjan Kumar, Shaifali, Rahul Upadhyay and Sushil K. Maurya* Asian J. Org. Chem. 7 (2018), 776-780.

“Unravelling 2-aminoquinazolin-4(3H)-one as an organocatalyst for the chemoselective reduction of nitroarenes” Maheshwar S. Thakur, Onkar S. Nayal, Rohit Rana, Manoranjan Kumar, Sushila Sharma, Neeraj Kumar and Sushil K. Maurya* New Journal of Chemistry 42 (2018) 1373 - 1378. 

“Ligand-free iron(II)-catalyzed N-alkylation of hindered secondary arylamines with non-activated secondary and primary alcohols via a carbocationic pathway” O. S. Nayal,  M. S. Thakur,  M. Kumar,  N. Kumar, Sushil K. Maurya*, Adv. Synth. Catal. 360 (2018),730-737.

“An eco-compatible strategy for the diversity-oriented synthesis of macrocycles exploiting carbohydrate-derived building blocks”. Sushil K. Maurya*, Rohit Rana Beilstein J. Org. Chem. 13 (2017), 1106-1118.

“Synthetic Studies Towards the Crassifoside F: Synthesis of Oxygen-Rich Bicyclic Core” Sushil K. Maurya* Asian J. Org. Chem. 6(2) (2017) 224-234. 

“Synthesis of skeletally-diverse alkaloid-like molecules: Exploitation of metathesis substrates assembled from triplets of building blocks” Sushil K. Maurya, Mark Dow, Stuart Warriner and Adam Nelson, Beilstein J. Org. Chem. 9, (2013),775–785.

"Synthesis of Skeletally-Diverse Alkaloid-like Small Molecules " Sarah Murrison, Sushil K. Maurya, Christian Einzinger, Ben McKeever-Abbas, Stuart Warriner and Adam Nelson, Eur. J. Org. Chem. (2011) 2354–2359.

"A screening pipeline for antiparasitic agents targeting Cryptosporidium inosine monophosphate dehydrogenase" Lisa Sharling, Xiaoping Liu, Deviprasad R. Gollapalli, Sushil K. Maurya, Lizbeth Hedstrom and Boris Striepen, PLoS Neglected Tropical Diseases 4 (8), (2010), e794.

"Triazole Inhibitors of Cryptosporidium parvum Inosine 5'-Monophosphate Dehydrogenase" Sushil K. Maurya, Deviprasad R. Gollapalli, Shivapriya Kirubakaran, Minjia Zhang, Corey R. Johnson, Nicole K. Benjamin, Lizbeth Hedstrom and Gregory D. Cuny, J. Med. Chem. 52 (2009) 4623-4630.

"Synthesis of spiroannulated dihydroisobenzofuranylated monosaccharides" Sushil K. Maurya and Srinivas Hotha, Tetrahedron Lett. 47, (2006) 3307-3310.

"Stereoselective synthesis of spiroannulated cyclopentenones by the Pauson–Khand reaction on carbohydrate derived enynes" Srinivas Hotha, Sushil K. Maurya and Mukund K. Gurjar, Tetrahedron Lett. 46, (2005) 5329-5332.

"Vapor phase oxidation of 4-fluorotoluene over vanadia–titania catalyst" Sushil K. Maurya, Pratap Patil, Shubhangi B. Umbarkar, Mukund K. Gurjar, Mohan Dongare, Stephan Rudiger, Erhard Kemnitz, J. Mol. Catal.  A: Chemical 234 (2005) 51–57.

"Solid acid catalysts for fluorotoluene nitration using nitric acid" Sushil K. Maurya, M. K. Gurjar, K. M. Malshe, P. T. Patil, M. K. Dongare and Erhard Kemnitz, Green Chemistry, 5 (2003) 720–723.

Granted

“1,6- DIAZABICYCLO [3,2,1] OCTAN- 7- ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS” Kale, Amol; Dond, Bharat; Dekhane, Deepak; Loganathan, V; Patel, Mahesh Vithalbhai; Pawar, Mangesh; Shaikh, Mohammad; Patel, Piyush; Dixit, Prasad; Tadiparthi, Ravikumar; Bhagwat, Sachin; Birajdar, Satish; Maurya, Sushil Kumar; Patil, Vijaykumar Jagdishwar; EP 2961751 B1.

“Compounds and methods for Treating Mammalian Gastrointestinal Microbial Infections” Hedstrom, Lizbeth, K.; Cuny, Gregory, D.; Gollapalli, Deviprasad, R.; Kirubakaran, Sivapriya; Maurya, Sushil K.;  Striepen, Boris; Gorla, Suresh K.; Johnson, Corey R.; Kavitha, Mandapati; Khan, Jihan; US 10,125,116 B1. 

“1,6- DIAZABICYCLO [3,2,1] OCTAN- 7- ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS” Kale, Amol; Dond, Bharat; Dekhane, Deepak; Loganathan, V; Patel, Mahesh Vithalbhai; Pawar, Mangesh; Shaikh, Mohammad; Patel, Piyush; Dixit, Prasad; Tadiparthi, Ravikumar; Bhagwat, Sachin; Birajdar, Satish; Maurya, Sushil Kumar; Patil, Vijaykumar Jagdishwar; US 9732081 B2.

Filed

 “N-(ALKANOYL)-7-OXO-6-SULFOOXY-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBONYL HYDRAZIDE DERIVATIVE AND THEIR USE AS ANTIBACTERIAL AGENTS. Patil, V. J.; Maurya, Sushil K., Patel, P. A.; Bhuniya, R.; Zaki Ahmad, B. M.; Patel, M. V. WO002017216764.

“Difluoro-(2-Substituted Carbamoyl-1,6-Diaza-Bicyclo [3.2.1] Oct-6-Yloxy) Acetic Acid Compounds and Their Use in Treatment of Bacterial Infections” Vijay J Patil, Sushil Kumar Maurya, Bharat Dond, V. Loganathan, Deepak Dekhane, Dixit, Prasad; Joshi, Prashant; Takalkar, Swapna; Mahesh Patel; WO 002017060826.

“AZETIDINONE CONTAINING COMPOUNDS AND THEIR USE IN TREATMENT OF BACTERIAL INFECTIONS” Patil, Vijaykumar Jagdishwar; Maurya, Sushil Kumar; Patel, Mahesh Vithalbhai; WO002016128867.

“Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections” Patil, V. J.; Maurya, Sushil K., Patel, P. A.; Bhuniya, R.; Zaki Ahmad, B. M.; Patel, M. V. IN/2016/21020850 Submitted 17/06/2016. 

“Insecticidal Properties of Sapium sebiferum for the Control of Insect Pests” S G Eswara Reddy, S. K. Dolma and Sushil K. Maurya Submitted to CSIR-IHBT Patent Unit 26th March 2019.

 

Present

(1) Dr. Avnish Kumar, Research Associate

(2) Amita Sharma, SRF, Ph. D Student

(3) Rohit Rana, SRF, Ph. D Student

(4) Rahul Upadhyay, SRF, Ph. D Student

(5) Arti Sharma, JRF, Ph. D Student

(6) Rahul Kumar, JRF, Ph. D Student

(7) Aakriti Sood, Project Fellow

(8) Shashi Kumar, Project Fellow

(9) Shreya, Project Fellow

(10) Deepak Dabur, Project Fellow

(11) Deepak Singh, Project Fellow

 

Group Alumni

Dr. Simmi Sharma, National Post-Doctoral Fellow 

Current: Post-Doctoral Fellow, Krembil Research Institute, University of Toronto, Canada

Past Ph. D Students

Dr. Onkar S. Nayal, (Awarded Feb. 2018) 

Current: Peking University Boya Post-Doctoral Fellowship, Beijing, China 

Dr. Maheswar S. Thakur, (Awarded Oct. 2018) 

Current: Kothari Post-Doctoral Fellowship; HPU, Shimla

 

Talented and highly motivated candidates with their own fellowship interested in doing research in medicinal chemistry, natural product synthesis and chemical biology are welcome to apply. Candidates interested in applying for their own postdoctoral/ Ph.D funding should contact with detailed CV and research interest.

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