Natural Product Chemistry and Process Development
Scientist
NMR, Metabolomics and Natural Product Chemistry
01894-230426, 233339 Ext. 462 (O); +919459344184
;
Ph.D. in Pharmaceutical Sciences (Pharmacognosy & Phytochemistry)

Please visit: https://sites.google.com/site/drdineshkumarcsirihbt/

Research Focus

From the primitive age, plants and marines have been used to cure serious complications of health and are still very significant. Their derived products are used either as such or template in the discovery of new drugs. Several biologically active secondary metabolites have been used for their medicinal values. Hence to understand the chemistry, metabolite composition and alterations in plant, marines and biofluids, along with quality profile and quality control, is the need of hours. We are currently working on metabolite profiling, and quality control of some medicinally important crops of western Himalaya using NMR, UPLC-MS/MS and HPTLC techniques. Moreover, we are also working to find out mechanistic role of medicinal plants and their derived products (Lower to Trans Himalaya) using modern analytical techniques based metabolomic approaches for toxicity, safety and action in health disorders such as Brain, cancer, diabetes, cardiovascular, inflammatory, respiratory, liver disorders.    

Major Research Interests 

·         Isolation and characterization of secondary metabolites from nature.

·         Pharmacognostical studies, standardization and evaluation of traditional medicines.

·         Development of analytical methods for quality control.

·         Herbal and Ayurvedic product development along with development of NDDS.

·         Plant metabolomics and marine drug discovery        

External Research Projects

S.No

Name of project

Funding agency

Sanctioned budget

(lacs)

Project duration

(Dates)

Working as PI/ Co-PI/ Co-I

 

From

to

1.

Myocardial lipidomics and metabolomic fingerprinting of Crataegus oxyacantha by NMR, LC-MS/MS techniques to delineate its toxicity/safety in cardiac disorders

SERB-DST, New Delhi, India

18.00

20.03.2014

19.03.2018

PI

2.

Characterization and Consolidation of Hippophae Genetic Resources and Propagation of Elite Genotypes for Varietal Evaluation

DBT, New Delhi, India

48.50

2014

2017

PI

3

Development of herbal formulations from Seabuckthorn

DBT, New Delhi, India

Net work Project

2017

 

2021

PI

             

Publication: Published-61 Accepted-03, Book Chapter-01

Book Chapter: Dinesh Kumar*, Zulfiqar Ali Bhat, Ramesh Deoda, Satish Mudgade,    Ishtiaq Chasoo and Vijender Kumar. Chapter-10: Bronchodilator activity in Traditional medicines: Gift of God Kingdom 2011; 171-190. 'Bronchitis', ISBN 978-953-307-198-5. INTECH open publisher, Ignacio Martín-loeches (Editor), T/F: +38551686166, E: : www.intechweb.org

Current Publication

·  Kumar S, Patial V, Soni S, Sharma S, Pratap K, Kumar D*, Padwad Y*. Picrorhiza kurroa enhances β-cell mass proliferation and insulin secretion in streptozotocin evoked β-cell damage in rats. Front. Pharmacol. 2017 (Accepted)

·   Gautam M, Acharya D, Bhat ZA, Kumar D*. Future Leads: Natural Products as Anti-infective Agent. The Natural Products Journal, 2017; 7(2): 84-96.

·   Rattan R*, Fozdar BI, Gautam V, Sharma R, Kumar D*, Sharma U*. Cuspidate A, New Anti-Fungal Triterpenoid Saponin from Lepidagathis cuspidate. Natural Product Research, 2017; 31(7): 773-779.

·   Shard A, Rawat K, Sinha AK, Padwad Y, Kumar D. Natural Product Salvianolic acid F-Inspired Divergent Synthesis of Styryl-Cinnamate Hybrid Analogues as a Premise to Investigate Anticancer Activity and its Metabolomic Profiling. European Journal of Organic Chemistry. 2016; 36:5941-5949.

·   Katoch P, Rana S, Kumar D*, Kumar S, Bhushan S. Concurrent NP-HPTLC determination of shikonin and β,β-dimethylacryl shikonin in Arnebia benthamii. Journal of Chromatographic Science. 2016; 54 (8): 1421-1427.

·   Kumar D*, Kumar R, Sing B, Ahuja PS. Comprehensive metabolomic profiling of an endangered medicinal plant Picrorhiza kurroa Royle ex Benth cultivated in Indian Himalayas. Combinatorial Chemistry & High Throughput Screening 2016: 19 (3): 200-215.

·   Rattan R, Kumari A, Gautam V, Fozdar BI, Sharma U, Kumar D*. Preliminary Phytochemical Screening, Antioxidant and Antifungal Activity of Lepidagathis cuspidateInt J Drug Dev & Res. 2016; 8(1): 1-3.

·   Kumar D*. Application of Nuclear magnetic resonance (NMR) spectroscopy: Promising analytical technique. Critical review in analytical chemistry 2016; 46(5): 400-412.

·   Kumar D*, Gulati A, Sharma U*. Determination of theanine and catechin in Camellia sinensis (Kangra Tea) leaves by HPTLC and NMR techniques. Food Analytical Methods 2016; 9: 1666. doi:10.1007/s12161- [Link]

·   Dongre P, Bhujbal SS, Kumar D*. Bronchodilatory activity of Curcuma longa, Zingiber officinale and Alpinia galanga based herbal formulation (AHF). Oriental Pharmacy and Experimental Medicine 2015; 15: 341-346. 

·   Kumar D*, Kumar R, Sing B, Ahuja PS. Reproducible RP-HPTLC based quality control method for endangered medicinal plant Picrorhiza kurroa Royle Ex Benth. Journal of Planar Chromatography 2015; 28(3): 256–261. 

Honours and Awards

Young Scientists, DST Fast track research grant- SERB, New Delhi, India, 2015-2018.

PDF, Tshwane University of Technology, Pretoria- South Africa (2012-2013).

INSA-CSIR-BRNS/DAE-CICS, India, Joint Traveling Grant, 2012 (Not availed).

Qualified HPPSC- Test for Reader in Pharmaceutical Sciences, India, 13-6-2012.

MPF, Fellowship, UGC-New Delhi-India, 1 May 2010 – 31 Jan 2013.

CSIR Traveling Grant, 2011.

University of Kashmir, Srinagar-190006, India, Special Travelling Grant, 2011.

1st prize and gold medal in debate held at IET Bhaddal, Punjab, 2005, India.

CET 60th rank in Maharashtra state, India for M. Pharm, 2007.

Editorial Board Member

·         TANG: International Journal of Genuine Traditional Medicine. The Marriage of Humanitas and Traditional Medicine. (Korea)

·         Platinum Global Journal Of Medicine And Medical Science

·         Archives of Depression and Anxiety

·         SM Tropical Medicine Journal

·         CRESSCO Journal of Depression and Anxiety (CJDA)

Society Member

Italo-Latin American Society of Ethnomedicine (137089223602301)

 Registered Pharmacist (HPSPC)

Ph. D Research Scholar

Miss Shruti Sharma

Project Fellow

Miss Krishna Thakur

 Prospective Team Members 


 Postdoctorate  and Ph.D positions are available for self-motivated persons.

 

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