Biotechnology (Bioinformatics)
Senior Scientist
Bioinformatics & Computational structural biology
+91-1894-233339 Ext 421
B.Pharmacy, M.Tech & Ph.D.
CV.pdf

My scientific interests focus on range of issues related to structural bioinformatics. By adopting multidisciplinary approach combines first-principle physics with the analysis of biological systems such as 3-dimensional structure of proteins, protein-drug complex and nucleic acids, I would like to observe that how certain mutation alter the dynamics behavior of proteins and its interaction with other molecules. I am very much interested in molecular folding, evolution, and binding interactions, and structure/function relationships of experimentally solved structures and from computational models.

Total publications: 62

H-index: 25

 

 GATE fellowship - MHRD Govt. of India

 Postdoctoral fellow - Human genetics foundation, Torino Italy (Web-link)

 Early Career Research Award (ECRA) by SERB-DST, Govt. of India

 

 

1) Kumar S, Sinha K, Sharma R, Purohit R*, Padwad Y*. Phloretin and phloridzin improve insulin sensitivity and enhance glucose uptake by subverting PPARγ/Cdk5 interaction in differentiated adipocytes. Exp Cell Res. 2019 Jul 4. pii: S0014-4827(19)30320-9. doi: 10.1016/j.yexcr.2019.06.025.

 

2) Tanwar G, Mazumder AG, Bhardwaj V, Kumari S, Bharti R, Yamini, Singh D, Das P, Purohit R*. Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures. Sci Rep. 2019 May 27;9(1):7904. doi: 10.1038/s41598-019-44264-6.

 

3) Rajendran V, Gopalakrishnan C, Purohit R*. Impact of point mutation P29S in RAC1 on tumorigenesis. Tumour Biol. 2016 Nov;37(11):15293-15304.

 

4) Purohit R*. Role of ELA region in auto-activation of mutant KIT receptor: a molecular dynamics simulation insight. J Biomol Struct Dyn. 2014;32(7):1033-46.

 

5) Kumar A, Purohit R*. Use of long term molecular dynamics simulation in predicting cancer associated SNPs. PLoS Comput Biol. 2014 Apr 10;10(4):e1003318. doi: 10.1371/journal.pcbi.1003318.

 

Visit Google Scholar Page

 

 

I am looking for highly motivated students with independent fellowship like CSIR/UGC/DBT/INSPIRE are welcome to contact. Candidates interested in applying for their own postdoctoral/ Ph.D funding should contact with detailed CV and research interest.

Current Group:

Graduate Students/ Research Fellows

 1.      Mr. Sachin Kumar, Ph.D candidate

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