Dietetics & Nutrition Technology (Formulation)
Scientist
Formulation & Drug Delivery
01894-233339 Ext: 485
24-07-1989
PhD
CV.pdf
(i) Development of value added products from aromatics and herbals
 

India is gifted with 8000 medicinal and 1200-2500 aromatic plants. They have been extensively used for the preparation of drugs in various systems of medicine, herbal cosmetics and functional foods. Further, essential oils from aromatic plants have also been extensively used in flavour, fragrance, cosmetics industries and in aromatherapy. The main focus of our laboratory is to develop value added products from medicinal and aromatic plants utilizing pharmaceutical technology (formulations) to produce commercially marketable products.

 
 
(ii) Development of nutraceutical formulations for improvement of bioavailability and therapeutic efficacy
 

The consumption of dietary phytochemicals is consistently linked with protection from chronic diseases such as diabetes, cardiovascular disease, cancer and neurodegenerative diseases. However, these phytochemicals have major therapeutic limitations because of their low aqueous solubility, low permeability, short half-life and low bioavailability to humans. These limitations can be overcome by advanced pharmaceutical technologies. The current theme of our laboratory is to utilize self-emulsifying drug delivery systems (SEDDS), solid dispersions, nano-emulsions and polymeric particles based approaches to enhance the bioavailability as well as therapeutic efficacy of nutraceuticals.

International Awards

CEFIPRA-ESONN fellowship for participation in “European School on Nanosciences and Nanotechnologies” on 28th August – 17th September, 2016 held at Grenoble, France.

PSE Travel Bursary for participation in “Natural Products in Health, Agro Food and Cosmetics” meeting from June 28th – July 1st, 2017 held at Lille, France.

Bioencapsulation Research Grant for participation in “25th International Conference on Bioencapsulation” on 3-6 July, 2017 held at Nantes, France.

Lapervenchelif award for participation in “The 5th AFERP International Conference "Pharmacognosy from Here and There" from July 17th to 19th 2017 held at Angers, France.

 FAPESP grant for attending "São Paulo School of Advanced Science on Reverse Engineering of Processed Foods” from September 25th – October 4th, 2017 held at at UNICAMP, Brazil.

DST-SERB International Travel Support for participation in “19th OXFORD ICSB, USA” on 8th April – 11th April, 2019 held at Oxford, Mississippi, USA.

 Achievements:

Qualified All India G.P.A.T. [Graduate Pharmacy Aptitude Test] 2010, 2012, G.A.T.E. [Graduate Aptitude Test in Engineering] 2012, 2016 Life Science (XL). (AIR: 303, GATE XL: 2016)

Selected Research Publications

Ruchika, Kumari S, Dhiman, P, Singh, D, Saneja, A.* 2022, R-α-Lipoic acid Conjugated to D-α-tocopherol polyethylene glycol 1000 succinate (TPGS): Synthesis, Characterization and Effect on Anti-Seizure Activity Journal of Agricultural and Food Chemistry 70, 25, 7674–7682.

Singhvi P, Saneja A., Ahuja R, Panda AK. (2021) Solubilization and refolding of variety of inclusion body proteins using a novel formulation, International Journal of Biological Macromolecules, 193, 2352-2364 [Link

Singhvi, P., Singh, A., Wani, T.Q., Qudratullah, M., Chakraborty, A., Saneja, A., Sarkar, D.P., Panda, A.K. (2021). Molecular attributes associated with refolding of inclusion body protein using freeze-thaw method. Frontiers in Microbiology, 12,719.

Kumar, R., Singh, M., Meena, J., Singhvi, P., Thiyagarajan, D., Saneja, A.*, Panda, A. K.* (2019). Hyaluronic acid-dihydroartemisinin conjugate: Synthesis, characterization and in vitro evaluation in lung cancer cells. International Journal of Biological Macromolecules, 133, 495-502. (*Corresponding Author)

Saneja, A., Kumar, R., Mintoo, M. J., Dubey, R. D., Sangwan, P. L., Mondhe, D. M., Panda A.K., Gupta, P. N. (2019). Gemcitabine and betulinic acid co-encapsulated PLGA− PEG polymer nanoparticles for improved efficacy of cancer chemotherapy. Materials Science and Engineering: C, 98, 764-771. 

Saneja, A., Kumar, R., Singh, A., Dubey, R. D., Mintoo, M. J., Singh, G., Mondhe, D.M., Panda, A.K., Gupta, P. N. (2017). Development and evaluation of long-circulating nanoparticles loaded with betulinic acid for improved anti-tumor efficacy. International Journal of Pharmaceutics, 531(1), 153-166. 

Saneja, A., Sharma, L., Dubey, R. D., Mintoo, M. J., Singh, A., Kumar, A., Sangwan, P.L., Abdullah, T., Singh, G., Mondhe, D.M., Gupta, P. N. (2017). Synthesis, characterization and augmented anticancer potential of PEG-betulinic acid conjugate. Materials Science and Engineering: C, 73, 616-626. 

Saneja, A., Nayak, D., Srinivas, M., Kumar, A., Khare, V., Katoch, A., Goswami, A., Vishwakarma, R.A., Sawant, S.D., Gupta, P.N. (2017). Development and mechanistic insight into enhanced cytotoxic potential of hyaluronic acid conjugated nanoparticles in CD44 overexpressing cancer cells. European Journal of Pharmaceutical Sciences, 97, 79-91

Dubey, R.D., Saneja, A., Qayum, A., Singh, A., Mahajan, G., Chashoo, G., Kumar, A., Andotra, S.S., Singh, S.K., Singh, G., Koul, S. (2016). PLGA nanoparticles augmented the anticancer potential of pentacyclic triterpenediol in vivo in mice. RSC Advances, 6(78), 74586-74597.

Arora, D., Dhanwal, V., Nayak, D., Saneja, A., Amin, H., Rasool, R., Gupta, P.N., Goswami, A. (2016). Preparation, characterization and toxicological investigation of copper loaded chitosan nanoparticles in human embryonic kidney HEK-293 cells. Materials Science and Engineering: C, 61, 227-234. 

Dubey, R.D., Alam, N., Saneja, A., Khare, V., Kumar, A., Vaidh, S., Mahajan, G., Sharma, P.R., Singh, S.K., Mondhe, D.M., Gupta, P.N. (2015). Development and evaluation of folate functionalized albumin nanoparticles for targeted delivery of gemcitabine. International Journal of Pharmaceutics, 492(1-2), 80-91.

Gupta, P.N., Jain, S., Nehate, C., Alam, N., Khare, V., Dubey, R.D., Saneja, A., Kour, S., Singh, S.K. (2014). Development and evaluation of paclitaxel loaded PLGA: poloxamer blend nanoparticles for cancer chemotherapy. International Journal of Biological Macromolecules, 69, 393-399.

Alam, N., Khare, V., Dubey, R., Saneja, A., Kushwaha, M., Singh, G., Sharma, N., Chandan, B., Gupta, P. N. (2014). Biodegradable polymeric system for cisplatin delivery: development, in vitro characterization and investigation of toxicity profile. Materials Science and Engineering: C, 38, 85-93. 

Khare, V., Kour, S., Alam, N., Dubey, R.D., Saneja, A., Koul, M., Gupta, A.P., Singh, D., Singh, S.K., Saxena, A.K., Gupta, P.N. (2014). Synthesis, characterization and mechanistic-insight into the anti-proliferative potential of PLGA-gemcitabine conjugate. International Journal of Pharmaceutics, 470(1-2), 51-62.

Selected Review Publications

Khan N, Ruchika, Dhritlahre, R. K., Saneja A* (2022), Recent advances in dual-ligand targeted nanocarriers for cancer therapy, Drug Discovery Today inpress  [Link]

Ruchika, Sharma A., Saneja A.* (2022) Zebrafish as A Powerful Alternative Model Organism for Preclinical Investigation of Nanomedicines, Drug Discovery Today, 27, 5, 1513 - 1522  [Link]

Dhritlahre, R. K., Ruchika, Padwad, Y., & Saneja, A.* (2021). Self-emulsifying formulations to augment therapeutic efficacy of nutraceuticals: From concepts to clinic. Trends in Food Science & Technology, 115, 347-365. [Link]

Dhritlahre, R. K., & Saneja, A.* (2021). Recent advances in HER2-targeted delivery for cancer therapy. Drug Discovery Today, 26, 1319-1329.  [Link]

Singhvi, P., Saneja, A., Srichandan, S., & Panda, A. K. (2020). Bacterial inclusion bodies: a treasure trove of bioactive proteins. Trends in Biotechnology, 38(5), 474-486.   [Link]

 Book Chapters

Saneja A, Nehate C, Alam N, Gupta PN, 2016, Chitosan based nanomedicines for cancer chemotherapy, In: Chitin and Chitosan for Regenerative Medicine, Ed: PK Dutta, In: Springer Series on Polymer and Composite Materials, pp 229-260 DOI: 10.1007/978-81-322-2511-9_9. 

Saneja A, Alam N, Dubey RD, Gupta PN, 2016, Recent advances in Self-emulsifying drug delivery for cancer chemotherapy, Ed: Alexandru Mihai Grumezescu In: Therapeutic nanostructures, Elsevier, pp. 379-404.

Books Edited:

Pharmaceutical Technology for Natural Products Delivery 1. Fundamentals and Applications, in series Sustainable Agriculture Reviews (SPRINGER NATURE, Switzerland) [ISBN: 978-3-030-41837-3]

Pharmaceutical Technology for Natural Products Delivery 2. Impact of Nanotechnology, in series Sustainable Agriculture Reviews (SPRINGER NATURE, Switzerland) [ISBN: 978-3-030-41841-0]

 PhD Fellow:
 
Mr. Rakesh Kumar Dhritlahre, JRF (UGC)
Ms. Ruchika, JRF (CSIR)
Mr. Nabab Khan (CSIR GPAT JRF)
Mr. Amit Kumar Singh, JRF (UGC)
 
Project Fellow:
 
Ms. Shagun Sanjivv Dogra (Project Associate I)
 
Group Alumni
 
Mr. Amit Sharma (Project Associate I)
 
Motivated aspirants having their own fellowship like CSIR/UGC/DBT/INSPIRE are welcome to contact.

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