Chemical Technology
Principal Scientist
NMR, Metabolomics and Natural Product Chemistry
01894-230426, 233339 Ext. 462 (O); +919459344184
Ph.D. in Pharmaceutical Sciences (Pharmacognosy & Phytochemistry)
Please visit: https://sites.google.com/view/drdineshhihbt/home
Research Focus
From the primitive age, plants and marines have been used to cure serious complications of health and are still very significant. Their derived products are used either as such or template in the discovery of new drugs. Several biologically active secondary metabolites have been used for their medicinal values. Hence to understand the chemistry, metabolite composition and alterations in plant, marines and biofluids, along with quality profile and quality control, is the need of hours. We are currently working on metabolite profiling, and quality control of some medicinally important crops of western Himalaya using NMR, UPLC-MS/MS and HPTLC techniques. Moreover, we are also working to find out mechanistic role of medicinal plants and their derived products (Lower to Trans Himalaya) using modern analytical techniques based metabolomic approaches for toxicity, safety and action in health disorders such as Brain, cancer, diabetes, cardiovascular, inflammatory, respiratory, liver disorders.
Major Research Interests
- Isolation and characterization of secondary metabolites from nature.
- Process development for the isolation of industrially important chemicals.
- Development and validation of quality control methods.
- NMR based chemical signatures for metabolomics and quality control.
- Metabolomics studies to understand the chemistry, metabolite formation and their up and down regulations in respect to biotic and abiotic factors.
- Pharmacognostical studies, standardization and evaluation of traditional medicines.
- Herbal and Ayurvedic product development including NDDS.
External Funded Projects
|
S.No
|
Name of project
|
Funding agency
|
Sanctioned budget
(lacs)
|
Project duration
(Dates)
|
Working as PI/ Co-PI/ Co-I
|
|
From
|
to
|
| 1. |
Myocardial lipidomics and metabolomic fingerprinting of Crataegus oxyacantha by NMR, LC-MS/MS techniques to delineate its toxicity/safety in cardiac disorders
|
SERB-DST, New Delhi, India
|
18.00
|
20.03.2014
|
19.03.2018
|
PI
|
| 2. |
Characterization and Consolidation of Hippophae Genetic Resources and Propagation of Elite Genotypes for Varietal Evaluation
|
DBT, New Delhi, India
|
48.50
|
2014
|
2017
|
PI
|
|
3.
|
Development of herbal formulations from Seabuckthorn
|
DBT, New Delhi, India
|
358.76943
|
2017
|
2021
|
PI
|
| 4. |
Ex-situ conservation and development of gene bank of four selected rare and threatened medicinal plants of cold desert region of Himachal Pradesh
|
HIMCOSTE- Shimla
|
5.10
|
2018
|
2020
|
Co-PI
|
| 5. |
Ex-situ conservation and development of gene bank of commercially important threatened medicinal plants in the high altitude areas, Himachal Pradesh
|
NMHS
|
70.713
|
2019
|
2023
|
PI member
|
| 6. |
Valorization of bioactive phytochemicals from underutilized tea plant parts and sustainable development of nutraceuticals/formulations
|
DST
|
14.82
|
2018
|
2021
|
Mentor
|
| 7. |
Exploration of the chemical and therapeutic potential of Viola species found in north western Himalayas for respiratory related problems
|
DST-INSPIRE
|
22.91
|
2019
|
2024
|
Mentor
|
| 8. |
Development of Bioelectronic Sensor Technology Coupled with High-Throughput Metabolomics for Quality Control of Jatamansi An Economically Important medicinal plant
|
DBT, New Delhi, India
|
Rs. 83.8868 lakhs (IHBT Component Rs 19.0588 lakhs)
|
2023
|
2026
|
PI
|
Technology transferred: 11 product transferred to more than 15 Technology partners as PI and Co-PI
Varieties developed: Developed as Co-PI by contributing through chemical analysis and variability studies. (PGRC: Plant germplasm registration committee-ICAR-NBPGR Delhi)
Germplasm Registered at NBPGR
- Germplasm CSIR-IHBT-ST-03 of Stevia rebaudiana (tetraploid) IC0635703, INGR20095 has been registered by Plant Germplasm Registration Committee (PGRC) of ICAR on 21st December, 2020
- Germplasm CSIR-IHBT-TM-09 of Tagetes minuta (wild marigold) IC0630603, INGR20103 has been registered by Plant Germplasm Registration Committee (PGRC) of ICAR on 21st December, 2020
- Germplasm CSIR-IHBT-TM-03 of Tagetes minuta (wild marigold) IC0630602, INGR20104 has been registered by Plant Germplasm Registration Committee (PGRC) of ICAR on 21st December, 2020
- Germplasm CSIR-IHBT-VJ-05 of Valeriana jatamansi (Indian valerian / Tagar) IC0630604, INGR20096 has been registered by Plant Germplasm Registration Committee (PGRC) of ICAR on 21st December, 2020
- Germplasm CSIR-IHBT-RD-04 of Damask rose IC0635435, INGR20105 has been registered by Plant Germplasm Registration Committee (PGRC) of ICAR on 21st December, 2020
- Germplasm CSIR-IHBT-VJ-08 of Valeriana jatamansi (Indian valerian) IC0630605, INGR20057 has been registered by Plant Germplasm Registration Committee (PGRC) of ICAR on 29th September, 2020
- Germplasm CSIR-IHBT-AM-02 of Artemisia maritima (Seaworm wood) IC0635705, INGR20060 has been registered by Plant Germplasm Registration Committee (PGRC) of ICAR on 29th September, 2020
- Germplasm CSIR-IHBT-DH-04 of Dracocephalum heterophyllum (white dragonhead) IC0635704, INGR20059 has been registered by Plant Germplasm Registration Committee (PGRC) of ICAR on 29th September, 2020
- Germplasm CSIR-IHBT-DH-04 of German Chammomill (INGR24046), 22 May, 2024.
- Germplasm CSIR-IHBT-DH-04 of True Lavender (INGR24047), 22 May, 2024
Memberships and Awards
- Member of scientific panel for functional foods, Nutraceuticals, Dietetic products and other Similar Products, FSSAI-India (2020-2023).
- Member and reporter of working group on method of analysis for ingredients and products covered under nutraceutical regulations, FSSAI-India (2020-2022).
- Member of Italo-Latin American Society of Ethnomedicine (137089223602301)
- Life Member of Vigyan Bharti (Vijnana Bharti), Nagpur, India (Serial Number: 283)
- Member of Society of ethnopharmacology, India (SFE/20/I-1636)
- Ultra international Pvt. Ltd travel and registration grant for international conference at Cyprus, 2019.
- NASIC-IDB and Bazimalam Vakif University, Travelling Grant as NMR expert in workshop at Bazimalam Vakif University, Istanbul-Turkey 2017.
- Start Up Research Grant (Young Scientists); DST Fast track- SERB, New Delhi, India, 2015-2018.
- Postdoctral fellowship, Tshwane University of Technology, Arcadia, Pretoria, South Africa
- INSA-CSIR-BRNS/DAE-CICS, India, Joint Traveling Grant for presenting a paper in international conference abroad, 2012 (Not availed).
- Qualified Screening test, Himachal Pradesh Public service commission, India 13-6-2012.
- MPF, Fellowship from University Grant Commission-New Delhi-India, 1 May 2010 – 31 Jan 2013.
- CSIR-India, Traveling Grant for presenting a paper in international conference abroad, 2011.
- University of Kashmir, Srinagar-190006, India, Special Traveling Grant for presenting a paper in international conference abroad, 2011.
Editorial Board Member
· TANG: International Journal of Genuine Traditional Medicine. The Marriage of Humanitas and Traditional Medicine. (Korea)
· Platinum Global Journal Of Medicine And Medical Science
· Archives of Depression and Anxiety
· SM Tropical Medicine Journal
· CRESSCO Journal of Depression and Anxiety (CJDA)
Patents
|
Sl No.
|
Title
|
Country
|
Filed on (Date)
|
Granted on (Date).
|
Names of other inventors
|
-
|
A nutraceutical formulation for improving qualitative and quantitative sleep
|
PCT-India
|
2024
|
Indian Application No. 20241100880
|
Dhiraj Vyas, Dinesh Kumar, PN Gupta, Damanpreet Singh
|
-
|
Phytosomes of polyphenol enriched
Extracted fraction of Hippophae rhamnoides l. Fruit and soyabean
Lecithin
|
PCT-India
|
2023/2024
|
Indian Application No. 202311020107
|
Singh, Inder
Pal, Gore
Dattatraya
Dinkar, Bansal,
Arvind K, Tiko0,
Kulbhushan, Jena,
Gopabandhu, Pant, Rajat, Ranjana,
Soni, Jachak,
Sanjay M, Kumar
Dinesh
|
-
|
Enhancing therapeutically important secondary metabolites in Picrorhiza kurrooa employing biological means
|
PCT-India
|
2025
(3-01-2025)
|
Indian Application No. 202511001024
|
Tamang Anish, Hallan Vipin, Pandey Shiv Shanker, Singh Rahul Mohan, Kumar Dinesh
|
-
|
In vitro system for production of naphthoquinone red pigments from adventitious roots of Arnebia euchroma
|
PCT-India
0064NF2021
|
04-10-2021
|
Indian Application No. 202111045278
|
Shashi Bhushan, Jyoti Devi, Roushan Kumar, Dinesh Kumar, Sanjay Kumar
|
Ph. D Research Scholar
Doctoral students supervised – completed & on-going
|
SI. No
|
Enrolment No.
|
Name of Student
|
Year of Award/ongoing
|
Subject faculty
|
Lab/Institute
|
Supervisor/co- supervisor
|
-
|
10BB16A33001
|
Dr Anamika Sharma
|
2020
|
Biological Sciences
|
CSIR-IHBT, Palampur
|
Co- supervisor
|
|
Title: Therapeutic potential of Berberis lycium royle fruits and underlying molecular mechanism in amelioration of ulcerative colitis and rheumatoid arthritis
|
-
|
10CC17J33013
|
Dr Ranjana Sharma
|
2022
|
Chemical Sciences
|
CSIR-IHBT, Palampur
|
Supervisor
|
|
Title: Phytochemical and value addition studies of unexplored commercially important parts of Camellia sinensis (L.) O. Kurtze
|
-
|
10CC16A33018
|
Dr Shruti Sharma
|
2022
|
Chemical Sciences
|
CSIR-IHBT, Palampur
|
Supervisor
|
|
Title: Exploration of Polygonatum verticillatum for its Chemistry and Therapeutic Potential
|
-
|
10BB17A33005
|
Mahinder Pratap
|
2023
|
Biological Sciences
|
CSIR-IHBT, Palampur
|
Co- supervisor
|
|
Title: Development of Plant Cell Culture System for Biomass production and Enhancement of Specialized metabolites in Picrorhiza kurroa (Royle ex Benth.): An Endangered Himalayan Medicinal Herb
|
-
|
10CC18A33019
|
Dinesh Kumar
|
2024
|
Chemical Sciences
|
CSIR-IHBT, Palampur
|
Supervisor
|
|
Title: Exploration of Trillium govanianum for its Chemistry and Therapeutic Potential
|
-
|
10CC21A33006
|
Shashi Kumar
|
2025
|
Chemical Sciences
|
CSIR-IHBT, Palampur
|
Supervisor
|
|
Title: Development of Novel Strategies for Carbon-Heteroatom (C-X) Bond Formation Reactions and Avibactum Synthesis
|
-
|
10CC19A33034
|
Rishabh Kaundal
|
2025
|
Chemical Sciences
|
CSIR-IHBT, Palampur
|
Supervisor
|
|
Title: Exploration of chemical and therapeutic potential of Viola canescens Wall. Ex Roxb. From western Himalayas
|
-
|
10CC20J33039
|
Vandana Kumari
|
2025
|
Chemical Sciences
|
CSIR-IHBT, Palampur
|
Supervisor
|
|
Title: Phytochemical investigation and therapeutic potential of Ajuga parviflora Benth
|
-
|
10CC20A33006
|
Rajender Kumar
|
Submitted
|
Chemical Sciences
|
CSIR-IHBT, Palampur
|
Supervisor
|
|
Title: Exploration of chemical and therapeutic potential of Allium semenovii Regel
|
|
10.
|
10BB19A33006
|
Kanika
|
ongoing
|
Biological Sciences
|
CSIR-IHBT, Palampur
|
Co- supervisor
|
|
Title: Enhancement of Biomass and specialized metabolites biosynthesis in Picrorhiza kurroa (Royle ex Benth.) under soiless conditions
|
|
11.
|
10BB20A33011
|
Virat Abhishek
|
ongoing
|
Biological Sciences
|
CSIR-IHBT, Palampur
|
Supervisor
|
|
Title: Exploration of Himalayan Ribes and Sea buckthorn for its chemistry and health benefits
|
|
12.
|
10CC20A33003
|
Shiv Kumar
|
ongoing
|
Chemical Sciences
|
CSIR-IHBT, Palampur
|
Supervisor
|
|
Title: Bioprospection of Bunium persicum (Boiss.) B.Fedtsch and Carum carvi L.: Himalayan species
|
|
13.
|
10CC20A33005
|
Bindu Rawat
|
ongoing
|
Chemical Sciences
|
CSIR-IHBT, Palampur
|
Supervisor
|
|
Title: Chemical prospection and value addition of Picrorhiza kurroa Royle ex Benth. For therapeutic potential
|
|
14.
|
10CC21J33004
|
Vijaylata
|
ongoing
|
Chemical Sciences
|
CSIR-IHBT, Palampur
|
Supervisor
|
|
Title: Bioprospection of industrially important medicinal plants viz., Artemisia maritima L. and Matricaria chamomilla L.
|
|
15.
|
10CC21A33001
|
Manish Kumar
|
ongoing
|
Chemical Sciences
|
CSIR-IHBT, Palampur
|
Supervisor
|
|
Title: Exploration of Inula racemosa Hook F. for its chemistry and therapeutic potential
|
|
16.
|
10CC21A33003
|
Anil Kumar
|
ongoing
|
Chemical Sciences
|
CSIR-IHBT, Palampur
|
Supervisor
|
|
Title: Investigation of Cordia myxa L. for its chemistry and value-added products
|
|
17.
|
H14836
|
Pallavi Kumari
|
on-going
|
Chemical Sciences
|
CPU,s Hamirpur, H.P.
|
Co-supervisor
|
|
Title: Identification, Isolation and characterization of Active Principals from Euphorbia royleana
|
Supervised other than Ph.D: MD: 11
Co-Superviser of MD student of Rajiv Gandhi Govt. Post Graduate Ayurvedic College Paprola, H.P. (India)
|
Sr. No.
|
Name of the Student
|
Title of the Thesis
|
Specialization of MD-Ayurveda
|
Submission Date
|
Year Of Award
|
|
1
|
Dr. Priyalkumari Pravinbhai Patel
|
A classical review on Pratinidhi Dravyas and phytopharmacognostical analysis on Langali (Gloriosa superba Linn.) and Sthaneyak (Taxus baccata Linn.) w.s.r to Kushtha (Saussurea lappa C.B. Clarke.) as their Pratinidhi
|
Dravyaguna
|
28-09-2024
|
2024
|
|
2
|
Dr. Ambika
|
Phytopharmacognostical & in vitro study of Choraka (Angelica glauca Edgew.) to evaluate its hypolipidemic & antioxidant activities
|
Dravyaguna
|
28-09-2024
|
2024
|
|
3
|
Dr. Kamakshi Joshi
|
A Pharmaceutico-Analytical Study of Kamadudha Rasa alaong with its Antimicrobial Activity against Helicobacter pylori
|
Rasa Shastra & Bhaishajya Kalpana
|
28-09-2024
|
2024
|
|
4
|
Dr. Ajay Yadav
|
Role of two different levigation media with respect to Pharmaceutico-Analytical and Antimicrobial studies of Mrityunjaya Rasa
|
Rasa Shastra & Bhaishajya Kalpana
|
28-09-2024
|
2024
|
|
5
|
Dr. Bharat Bhushan
|
An Experimental Randomized Control Trial on the Hepatoprotective Effect of Shirishadi Yoga in Acetaminophen Induced Hepatoxicity
|
Agada Tanta Evum Vidhi Vadyaka
|
28-09-2024
|
2024
|
|
6
|
Dr. Sahil Guleria
|
Pharmaceutico-Analytical Study of Mutradahaantak Churna w.s.r to its In Vitro Antimicrobial Activity on Pathogens Causing Urinary Tract Infection
|
Rasa Shastra & Bhaishajya Kalpana
|
28-09-2024
|
2024
|
|
7
|
Dr. Ritika
|
A Pharmacognostical and Phytochemical Study on Pullaas (Rhododendron arboreum Sm.) and to evaluate its Clinical Effect on Shweta Pradara w.s.r to Non-specific Vaginal Discharge
|
Dravyaguna
|
11-09-2023
|
2023
|
|
8
|
Dr. Ram Deo Pandit
|
Experimental Study of Van-lahsun (Frillaria roylei Hook.) to evaluate its anti-inflammatory activity on lower respiratory system (LRS)
|
Dravyaguna
|
11-09-2023
|
2023
|
|
9
|
Dr. Sunil Sharma
|
A Pharmacognostical Study on Pushkarmool (Inula racemosa) for its identification and comparative study to evaluate the antihistamic effect of Pushkarmool (Inula racemosa Hook. f.) and Kushth (Saussurea lappa Decne. C.B. Clarke) in an experimental model
|
Dravyaguna
|
11-09-2023
|
2023
|
|
10
|
Dr. Sukriti Sharma
|
An Experimental Randomized Control Trial on the Hepatoprotective Effect of Mahaagada in Acetaminophen Induced Hepatoxicity
|
Agada Tanta Evum Vidhi Vadyaka
|
11-08-2023
|
2023
|
|
11
|
Dr. Bishun Dayal Prasad Patel
|
A comparative experimental study of Selinum vaginatum C.B Clarke and Nardostachys jatamansi DC. With special references to their antihypertensive activity.
|
Dravyaguna
|
2016-2017
|
2017
|
Training imparted (M.Pharm, MSc students)
- Ms. Ankita Rani (2024) Extraction, fractionation, isolation of molecules from natural matrices along with chromatography (UPLC-PDA) and In-vitro biological assays From Central University of Haryana Jant-Pali, Mahendergarh, Haryana Supervised by Dr. Dinesh Kumar (25-02-202025 to 24-03-2025).
- Ms. Nikita (2024) Extraction, fractionation, isolation of molecules from natural matrices along with chromatography (UPLC-PDA) and In-vitro biological assays From Central University of Haryana Jant-Pali, Mahendergarh, Haryana Supervised by Dr. Dinesh Kumar (25-02-202025 to 24-03-2025).
- Mr. Priyanshu (2024) Experiential learning on Analytical techniques (UPLC-PDA, LC-MS/MS), Column chromatography, Phyto-nanosponge, and herbal soap From Department of Chemical Engineering, National Institute of Technology, Hamirpur, Himachal Pradesh Supervised by Dr. Dinesh Kumar (13-05-202024 to 26-06-2024).
- Ms. Ayushi Walia (2024) Hands-on training on column chromatography and analytical methods used in natural product research From Ward No. 02, Village Kir chamba, P.O. Hatwas, Tehsil Nagrota Bagwan, District Kangra, Himachal Pradesh Supervised by Dr. Dinesh Kumar (05-04-202024 to 29-09-2024).
- Ms. Neha Thakur (2024) Phytochemical & Therapeutic potentials of Urtica dioica from Department of Pharmacy, School of Pharmaceutical and Health Sciences, Career Point University, Hamirpur, Himachal Pradesh Supervised by Dr. Dinesh Kumar (1-07-202023 to 30-06-2024).
- Ms. Avni Sood, (2024) Hands on training for chromatography (column chromatography and Ultra-performance liquid chromatography) From School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi Supervised by Dr. Dinesh Kumar (10-06-202024 to 09-07-2024).
- Ms. Anshika, (2024) Hands on training for chromatography (column chromatography and Ultra-performance liquid chromatography) From Khalsa College of Pharmacy & Technology, Amritsar, Punjab Supervised by Dr. Dinesh Kumar (07-06-202024 to 06-07-2024).
- Miss Aman Patial, Preparation and characterization of phytosomal-phospholipid complex of bioactive fraction of Polygonatum verticillatum. Sri Sai College of Pharmacy, Pathankot, Punjab Technical University, Jalandhar (Punjab), 2016
- Miss Malvika Rana, Preparation and characterization of phytosomal-phospolipid complex of bioactive fraction of zanthoxylum armatum, Sri Sai College of Pharmacy, Pathankot, Punjab Technical University, Jalandhar (Punjab), 2016
- Ms. Kirti, Chemical and biological investigation of Picrorhiza kurroa leaves found in western Himalaya. Faculty of Pharmaceutical Studies, Uttarakhand Technical University, (UK), 2016-2017.
- Nittya K. Dogra, Chemical Prospection of Vernonia species, Punjabi University Patiala, India. April 2017-Nov.2017.
- Miss. Sheetal Sharma, Extraction and sample preparation for analytical techniques, GC-MS, FTIR spectroscopy, Total phenolics, flavanoids and antioxidant assay. Junior Research Fellow, GBPNIHESD, Himachal Unit, Mohal-Kullu (HP) 175126, 2017
- Miss. Monika, Isolation of secondary metabolites using different chromatographic techniques. June– July 2017. Amity University, India.
- Miss. Komal, Hands on chromatographic techniques, Amity University, Haryana, 2017
- Miss. Diksha, Extraction, fractionation and isolation of bioactive molecules from Plant matrix (Tea). Dolphin PG College of Science & Agriculture, (Pb), 2017
- Miss. Diksha Dogra, Chemical Investigation of Sea Buckthorn (Hippophae rhamnoides) Berries using Chromatographic Techniques. Department of Chemistry, Amity School of Applied Sciences Gurgaon, 2016
- Miss Svati Kaushal, Chemical fingerprinting of Camellia sinensis cultivated in North-Western Himalayas. NIT Jalandhar, 2014
- Miss Swati, Chemical fingerprinting of Stevia rebaudiana. 2014
Project Fellow
Mr. Sachin Vashisath, Iva, Sweety
Prospective Team Members: Shiv Kumar, Virat Abhishek, Pawan Kumar, Vijaylata
Postdoctorate and Ph.D positions are available for self-motivated persons.
