Please visit: https://sites.google.com/site/drdineshkumarcsirihbt/

Research Focus

From the primitive age, plants and marines have been used to cure serious complications of health and are still very significant. Their derived products are used either as such or template in the discovery of new drugs. Several biologically active secondary metabolites have been used for their medicinal values. Hence to understand the chemistry, metabolite composition and alterations in plant, marines and biofluids, along with quality profile and quality control, is the need of hours. We are currently working on metabolite profiling, and quality control of some medicinally important crops of western Himalaya using NMR, UPLC-MS/MS and HPTLC techniques. Moreover, we are also working to find out mechanistic role of medicinal plants and their derived products (Lower to Trans Himalaya) using modern analytical techniques based metabolomic approaches for toxicity, safety and action in health disorders such as Brain, cancer, diabetes, cardiovascular, inflammatory, respiratory, liver disorders.    

Major Research Interests 

• Isolation and characterization of secondary metabolites from nature.
• Process development for the isolation of industrially important chemicals.
• Development and validation of quality control methods.
• NMR based chemical signatures for metabolomics and quality control.
• Metabolomics studies to understand the chemistry, metabolite formation and their up and down regulations in respect to biotic and abiotic factors.
• Pharmacognostical studies, standardization and evaluation of traditional medicines.
• Herbal and Ayurvedic product development including NDDS.

Publications

1. Bhattacharyya P, Kumar S, Lalthafamkimi L, Sharma R, Kumar D, Singh D, Kumar S. Molecular and phytomedicinal stability of long term micropropagated Malaxis acuminata: An endangered terrestrial orchid of biopharmaceutical importance. South African Journal of Botany. 2023 Apr 1;155: 372-382. IF: 3.31
2. Kumar R, Kumar D*. Comprehensive metabolomics and antioxidant activity of Allium species viz Allium semenovii, A. sativum and A. cepa: an important spice. Food Research International. 2023: 112584. IF: 7.425.
3. Walia S, Kumar P, Kumar D*, Kumar R*. A preliminary study on suitability of growing ginseng (Panax ginseng Meyer) in the Western Himalayan region. Plant Soil Environ. 2023;69. IF: 2.328
4. Kumari V, Kumar D, Bhardwaj R, Kumar D*. Metabolome analysis, nutrient and antioxidant potential of aerial and underground parts of Ajuga parviflora Benth. Microchemical Journal. 2023: 108451. IF: 5.304
5. Sood A, Thakur K, Joshi R, Kumar D, Warghat AR. Comparative quantification of dactylorhin among different wild tissues and in vitro cultures of Dactylorhiza hatagirea (D. Don), an endangered medicinal orchid of Western Himalayas. South African Journal of Botany. 2023; 153: 172-7. IF: 3.31
6. Shakeya P, Thakur R, Sharan H, Yadav N, Kumar M, Chauhan R, Kumar D, Kumar A, Singh S, Singh S*. GE biplot and regression based multi-environment investigations for higher yield and essential oil content in German chamomile (Matricaria chamomilla L.). Industrial Crops & Products. 2023, 193: 116145. IF: 6.449
7. Kumar D, Kumari V, Kumar D*. Metabolite profiling, antidiabetic, and antioxidant potential of different tissues of Trillium govanianum Wall. ex D. Don. South African Journal of Botany. 2023: 23: 102-108. IF: 3.31
8. Rattan S, Kumar D*, Warghat AR. The influence of phenylalanine feeding on cell growth, antioxidant activity, phenylpropanoids content, and yield in cell suspension culture of Rhodiola imbricata (Edgew.). Plant Cell, Tissue and Organ Culture (PCTOC). 2022 Nov;151(2):347-59. IF: 2.726
9. Devi J, Kumar A, Kumar D, Bhushan S. Adventitious root cultures of Arnebia euchroma: A sustainable alternative for the production of natural pigments. Industrial Crops and Products. 2022 Nov 1;187: 115461. IF: 6.449
10. Kumari V, Joshi R, Chawla A, Kumar D*. Metabolome analysis of Dactylorhiza hatagirea (D. Don) Soo reveals a significant antioxidant and nutritional potential of its tubers. South African Journal of Botany. 2022 Nov 1; 150:431-442. IF:3.31
11. Partap M, Rattan S, Kumar D*, Warghat AR. Bioprocess development for enhancing cell biomass, differential picrosides accumulation, and gene expression profiling at shake flask levels in suspension cultures of Picrorhiza kurroa. Industrial Crops and Products. 2022 Nov 1;187: 115311. IF: 6.449
12. Bhattacharyya P, Lalthafamkimi L, Sharma T, Kumar D, Kumar A, Kumar S. Metabolic and tissue-specific expression profiling in micropropagated plants of Malaxis acuminata: An endangered medicinal orchid. Plant Cell, Tissue and Organ Culture (PCTOC). 2022 Oct 7:1-5. IF: 2.726
13. Yadav N, Shakya P, Kumar A, Gautam RD, Chauhan R, Kumar D, Kumar A, Singh S, Singh S. Investigation on pollination approaches, reproductive biology and essential oil variation during floral development in German chamomile (Matricaria chamomilla L.). Scientific Reports. 2022;12(1):1-3. IF: 4.996
14. Partap M, Kumar P, Kumar P, Kumar D*, Warghat AR. Growth kinetics, metabolites production and expression profiling of picrosides biosynthetic pathway genes in friable callus culture of Picrorhiza kurroa Royle ex Benth. Applied Biochemistry and Biotechnology. 2020 Dec;192(4):1298-317. IF: 3.094
15. Sharma R, Kumar D*. Polyphenol Encapsulates from the Waste Biomass of C. sinensis and Their Simulated Oral, Gastric, and Intestinal Stability Studies: Nutraceutical Application. ACS Food Sci. Technol. 2022, 2, 8, 1257–1265. IF:
16. Kumari A, Kumar D*, Gulati A, Maurya SK. Mechanistic studies on polyphenol rich fractions of Kangra tea by HPTLC and NMR for their antioxidant activities. Journal of Food Science and Technology. 2022:59 (7): 2751-2763. IF: 3.117
17. Kaundal R, Kumar M, Kumar S, Singh D, Kumar D*. Polyphenolic Profiling, Antioxidant, and Antimicrobial Activities Revealed the Quality and Adaptive Behavior of Viola Species, a Dietary Spice in the Himalayas. Molecules. 2022 Jan;27(12): 3867. IF: 4.927
18. Partap M, Chhimwal J, Kumar P, Kumar D*, Padwad Y, Warghat AR. Growth dynamics and differential accumulation of picrosides and its precursor metabolites in callus cell lines of Picrorhiza kurroa with distinct anti-steatotic potential. Process Biochemistry. 2022 Jun 6. IF: 4.885
19. Sinha K, Kumar S, Rawat B, Singh R, Purohit R, Kumar D*, Padwad Y. Kutkin, Iridoid glycosides enriched fraction of Picrorrhiza kurroa promotes insulin sensitivity and enhances glucose uptake by activating PI3K/Akt signaling in 3T3-L1 adipocytes. Phytomedicine. 2022 May 25:154204. IF: 6.656
20. Partap M, Kumar P, Kumar P, Pal PK, Kumar D, Warghat AR, Kumar S. Fruit derived callus and cell suspension culture as promising alternative sources for mogrosides production in Siraitia grosvenorii (Swingle) C. Jeffrey: a zero-caloric natural sweetener. Journal of Food Composition and Analysis. 2022 May 1; 108: 104450. IF: 4.52
21. Joshi R, Sharma S, Kumar D*. Advances of Ion Mobility Platform for Plant Metabolomics. Critical Reviews in Analytical Chemistry. 2022 Apr 26:1-7. IF: 5.686
22. Kumar A, Joshi R, Vasishth A, Guleria V, Kumar D*. UHPLC-QTOF-IMS-Based Metabolite Fingerprinting of Underutilized Cordia myxa Fruits and Leaves: A Nutraceutical Source. ACS Food Science & Technology. 2022 Apr 20;2(5):793-807. IF:
23. Sharma A, Tirpude NV, Bhardwaj N, Kumar D, Padwad Y. Berberis lycium fruit extract and its phytoconstituents berberine and rutin mitigate collagen–CFA-induced arthritis (CIA) via improving GSK3β/STAT/Akt/MAPKs/NF-κB signaling axis mediated oxi-inflammation and joint articular damage in murine model. Inflammopharmacology. 2022 Apr;30(2):655-66. IF: 5.093
24. Sharma R, Kapoor S, Padwad Y, Kumar D*. GC-MS Based Profiling, Antimicrobial Activity and Cytotoxicity Studies of Camellia sinensis (L.) O. Kuntze Flower Extract. Journal of Biologically Active Products from Nature. 2022 Mar 4;12(2):137-45.
25. Rawat B, Bhatia P, Kumar M, Kumar P, Kumar D*. Determination of Picrosides, Phenolics and Cucurbitacins by Ultra-High Performance Liquid Chromatography-Diode Array Detection in Picrorhiza kurroa Royle Ex Benth. Journal of Analytical Chemistry. 2022 Jan;77(1):87-93. IF: 1.237
26. Sharma R, Kumar S, Kapoor S, Padwad Y, Kumar D*. Nuclear magnetic resonance-based metabolomics and cytotoxicity (HT-29 and HCT-116 cell lines) studies insight the potential of less utilized parts of Camellia sinensis (Kangra tea). Food Chemistry. 2022 Mar 30; 373: 131561. IF: 9.231
27. Raj D, Sharma V, Upadhyaya A, Kumar N, Joshi R, Acharya V, Kumar D, Patial V. Swertia purpurascens Wall ethanolic extract mitigates hepatic fibrosis and restores hepatic hepcidin levels via inhibition of TGFβ/SMAD/NFκB signaling in rats. Journal of Ethnopharmacology. 2022 Feb 10; 284: 114741. IF: 5.195
28. Gautam M, Chahota RK, Kumar D*. Nuclear magnetic resonance‐based chemical signature and nutritional discrimination of Macrotyloma uniflorum accessions from the alpine Himalayas. Journal of the Science of Food and Agriculture. 2022 Jan 30;102(2):707-15. IF: 4.125
29. Kumar A, Chauhan S, Rattan S, Warghat AR, Kumar D, Bhargava B. In vitro propagation and phyto-chemical assessment of Cymbidium aloifolium (L.) Sw.: An orchid of pharma-horticultural importance. South African Journal of Botany. 2022 Jan 1;144: 261-9. IF: 3.31
30. Gehlot A, Chaudhary N, Devi J, Joshi R, Kumar D, Bhushan S. Induction and submerged cultivation of Valeriana jatamansi adventitious root cultures for production of valerenic acids and its derivatives. Plant Cell, Tissue and Organ Culture (PCTOC). 2022 Feb;148(2):347-61. IF: 2.726
31. Rattan S, Kumar A, Kumar D*, Warghat AR. Enhanced Production of Phenylethanoids Mediated Through Synergistic Approach of Precursor Feeding and Light Regime in Cell Suspension Culture of Rhodiola imbricata (Edgew.). Applied Biochemistry and Biotechnology. 2022 Mar 29:1-9. IF: 3.094
32. Kumar A, Gautam RD, Kumar R, Chauhan R, Kumar M, Singh S, Kumar D, Singh S, Kumar A. Floral studies of palmarosa [Cymbopogon martinii (Roxb.) W. Watson] and chemical insights during inflorescence development. Industrial Crops and Products. 2021 Nov 1; 171: 113960. IF: 6.449
33. Kumar D, Joshi R, Sharma A, Nadda G, Kumar D*. A Comprehensive Search of the Primary and Secondary Metabolites and Radical Scavenging Potential of Trillium govanianum Wall. ex D. Don. Chemistry & Biodiversity. 2021 Oct;18(10):e2100300. IF: 2.745
34. Sharma S, Joshi R, Kumar D*. Metabolomics insights and bioprospection of Polygonatum verticillatum: An important dietary medicinal herb of alpine Himalaya. Food Research International. 2021 Oct 1;148: 110619. IF: 7.425
35. Singh R, Bhardwaj VK, Sharma J, Kumar D, Purohit R. Identification of potential plant bioactive as SARS-CoV-2 Spike protein and human ACE2 fusion inhibitors. Computers in Biology and Medicine. 2021 Jul 8:104631. IF: 6.698
36. Sharma R, Verma S, Kumar D*. Polyphenolics and therapeutic insights in different tissues extract and fractions of Camellia sinensis (L.) Kuntze (Kangra Tea). Food Bioscience. 2021 May 27:101164. IF: 5.318
37. Raj Y, Kumar A, Das S, Srivatsan V, Kumar D, Kumar R. A comparative analysis of compositional and phytochemical attributes in fruits of low chilling apple varieties cultivated in the eastern and western Himalaya. Scientia Horticulturae. 2021 Aug 25; 286: 110221. IF: 4.342
38. Rathore N, Thakur D, Kumar D, Chawla A, Kumar S. Time‐series eco‐metabolomics reveals extensive reshuffling in metabolome during transition from cold acclimation to de‐acclimation in an alpine shrub. Physiologia Plantarum. 2021 Dec;173(4):1824-40. IF: 5.081
39. Rattan S, Kumar D*, Warghat AR. Growth kinetics, metabolite yield, and expression analysis of biosynthetic pathway genes in friable callus cell lines of Rhodiola imbricata (Edgew). Plant Cell, Tissue and Organ Culture (PCTOC). 2021 Mar 25:1-2. IF: 2.726
40. Thakur BK, Mallikarjun CP, Mahajan M, Kapoor P, Malhotra J, Dhiman R, Kumar D, Pal PK, Kumar S. Introduction, adaptation and characterization of monk fruit (Siraitia grosvenorii): a non-caloric new natural sweetener. Scientific Reports. 2021 Mar 18;11(1):1-3. IF: 4.996
41. Gautam RD, Kumar A, Kumar R, Chauhan R, Singh S, Kumar M, Kumar D, Kumar A, Singh S. Clonal Propagation of Valeriana jatamansi Retains the Essential Oil Profile of Mother Plants: An Approach Toward Generating Homogenous Grade of Essential Oil for Industrial Use. Frontiers in Plant Science. 2021:2347. IF: 6.627
42. Sharma S, Chhimwal J, Kumar S, Padwad Y, Kumar D*. Cytotoxic steroidal saponins from Polygonatum verticillatum Linn. Phytochemistry Letters. 2021 Oct 1; 45: 30-36. IF: 1.873
43. Thakur K, Sood A, Kumar P, Kumar D*, Warghat AR. Steviol glycoside accumulation and expression profiling of biosynthetic pathway genes in elicited in vitro cultures of Stevia rebaudiana. In Vitro Cellular & Developmental Biology-Plant. 2021 Jan 26:1-1. IF: 2.347
44. Dhiman N, Kumar A, Kumar D*, Bhattacharya A*. De novo transcriptome analysis of the critically endangered alpine Himalayan herb Nardostachys jatamansi reveals the biosynthesis pathway genes of tissue-specific secondary metabolites. Scientific reports. 2020; 10(1):1-3. IF:4.996
45. Partap M, Kumar P, Kumar A, Joshi R, Kumar D*, Warghat AR. Effect of elicitors on morpho-physiological performance and metabolites enrichment in Valeriana jatamansi cultivated under aeroponic conditions. Frontiers in Plant Science. 2020; 11: 1263. IF: 6.627
46. Sharma A, Sharma R, Kumar D, Padwad Y. Berberis lycium Royle fruit extract mitigates oxi-inflammatory stress by suppressing NF-κB/MAPK signalling cascade in activated macrophages and Treg proliferation in splenic lymphocytes. Inflammopharmacology. 2020 Aug;28(4):1053-72. IF: 5.093
47. Partap M, Kumar P, Kumar P, Kumar D*, Warghat AR*. Growth Kinetics, Metabolites Production and Expression Profiling of Picrosides Biosynthetic Pathway Genes in Friable Callus Culture of Picrorhiza kurroa Royle ex Benth. Applied Biochemistry and Biotechnology. 2020 Jul 28:1-20. IF: 3.094
48. Rattan S, Sood A, Kumar P, Kumar A, Kumar D*, Warghat AR*. Phenylethanoids, phenylpropanoids, and phenolic acids quantification vis-à-vis gene expression profiling in leaf and root derived callus lines of Rhodiola imbricata (Edgew.). Industrial Crops and Products. 2020 Oct 15; 154:112708. IF: 6.449
49. Kumar R*, Joshi R, Kumari M, Thakur R, Kumar D*, Kumar S*. Elevated CO2 and temperature influence key proteins and metabolites associated with photosynthesis, antioxidant and carbon metabolism in Picrorhiza kurroa. Journal of Proteomics. 2020: 103755. IF: 3.855
50. Dogra NK, Kumar S, Kumar D*. Vernonia anthelmintica (L.) Willd.: An ethnomedicinal, phytochemical, pharmacological and toxicological review. Journal of Ethnopharmacology. 2020; 256: 112777. IF: 5.195
51. Sharma S, Joshi R, Kumar D*. Quantitative analysis of flavonols, flavonol glycoside and homoisoflavonoids in Polygonatum verticillatum using UHPLC-DAD-QTOF-IMS and evaluation of antioxidant potential. Phytochemical analysis. 2020; 31(3):333-339. IF: 3.024
52. Sharma D, Saini S, Kumar D, Kaur I, Kaur S. Assessment of sorption potential of paddy straw biochar for lead (pb2+) removal from waste water.Pollution Research. 2019; 38 (2): S98-S108, Suppl Issue.
53. Thakur K, Partap M,Kumar D*, Warghat AR. Enhancement of picrosides content in Picrorhiza kurroa Royle ex Benth. mediated through nutrient feeding approach under aeroponic and hydroponic system. Industrial Crops & Products 133 (2019) 160–167. IF: 6.449
54. Kumar D*, Thakur K, SharmaS, Kumar S. NMR for metabolomics studies of Crataegus rhipidophylla Gand. Analytical and Bioanalytical Chemistry. 2019. 411: 2149-2159. IF: 4.478
55. Joshi R, Sharma A, Thakur K, Kumar D*, Nadda G*. Metabolite analysis and nucleoside determination using reproducible UHPLC-Q-ToF-IMS in Ophiocordyceps sinensis. Journal of liquid chromatography & related technologies. 2018: 41:15-16, 927-936. IF: 0.827
56. Sharma S,Patial V,Singh D,Sharma U,Kumar D*. Antimicrobial homoisoflavanoids from the rhizomes of Polygonatum verticillatum.Chemistry & Biodiversity 2018;IF-1.617
57. Dogra NK, Kumar S, Thakur K, Kumar D*. Antipsoriatic effect of fatty acid enriched fraction of Vernonia anthelmintica Willd. fruits. Journal of ethnopharmacology. 2018; 224; 85-90.IF: 5.195
58. Kumar D*, Kumar P, Sharma U. UPLC-DAD-MS based quality control and discrimination analysis of different aerial parts of Crataegus rhipidophylla Gand. found in Indian western Himalaya. Analytical chemistry Letter. 2018; 8(2): 177-187.
59. Kumar D* and Sharma U. High-performance thin-layer chromatography: An economical alternative for the quality control of medicinal plants and derived products. Separation Science Plus. 2018; 1(2):100-134.
60. Sharma R, Jandroti R, Singh B, Sharma U and Kumar D*.Comprehensive metabolomics study of traditionally important Rumex species found in western himalayan region. Natural Product Communication. 2018, 13: 1-6. IF: 1.496
61. Sharma S, Sharma P, Kulurkar P, Singh D, Kumar D*, Patial V. Iridoid glycosides fraction from Picrorhiza kurroa attenuates cyclophosphamide-induced renal toxicity and peripheral neuropathy via PPAR-γ mediated inhibition of inflammation and apoptosis. Phytomedicine. 2017, 36, 108-17. IF: 6.656
62. Kumar S, Patial V, Soni S, Sharma S, Pratap K, Kumar D*, Padwad Y*. Picrorhiza kurroa Enhances β-Cell Mass Proliferation and Insulin Secretion in Streptozotocin Evoked β-Cell Damage in Rats. Frontiers in Pharmacology. 2017, 8, 537. IF: 5.988
63. Gautam M, Acharya D, Bhat ZA, Kumar D*. Future Leads: Natural products as anti-infective agent. The Natural Products Journal, 2017, 7, 1-13.
64. Rattan R, Fozdar BI, Gautam V, Sharma R, Kumar D*, Sharma U*. Cuspidate A, New anti-fungal triterpenoid saponin from Lepidagathis cuspidate. Natural Product Research, 2017, 31(7), 773-779. IF 2.488
65. Shard A, Rawat K, Sinha AK, Padwad Y, Kumar D. Natural product salvianolic acid F-inspired divergent synthesis of styryl-cinnamate hybrid analogues as a premise to investigate anticancer activity and its metabolomic profiling. European Journal of Organic Chemistry. 2016; 36: 5941–5949. IF: 3.261
66. Katoch P, Rana S, Kumar D*, Kumar S, Bhushan S. Concurrent NP-HPTLC determination of shikonin and β,β-dimethylacryl shikonin in Arnebia benthamii. Journal of Chromatographic Science. 2016; 1-7. IF: 1.6
67. Rattan R, Kumari A, Gautam V, Fozdar BI, Sharma U*, Kumar D*. Preliminary phytochemical screening, antioxidant and antifungal activity of Lepidagathis cuspidate. Int J Drug Dev & Res. 2016; 8(1): 001-3. IF: 1.95
68. Kumar D*.Nuclear magnetic resonance (NMR) spectroscopy for metabolic profiling of medicinal plants and their products. Critical review in analytical chemistry 2016; 46(5): 400-412. IF: 5.686
69. Kumar D*, Gulati A, Sharma U*. Determination of theanine and catechin in Camellia sinensis (Kangra Tea) leaves by HPTLC and NMR techniques. Food Analytical Methods 2016; 9: 1666–1674. IF: 3.498
70. Kumar D*, Kumar R, Singh B, Singh Ahuja P. Comprehensive chemical profiling of Picrorhiza kurroa Royle ex Benth using NMR, HPTLC and LC-MS/MS techniques. Combinatorial Chemistry & High Throughput Screening. 2016: 19(3): 200-215. IF: 1.714
71. Dongre P, Bhujbal SS, Kumar D*. Bronchodilatory activity of Curcuma longa, Zingiber officinale and Alpinia galanga based herbal formulation (AHF). Oriental Pharmacy and Experimental Medicine. 2015; 15: 341-346.
72. Kumar D*, Kumar R, Sing B, Ahuja PS. Reproducible RP-HPTLC based quality control method for endangered medicinal plant Picrorhiza kurrooa Royle Ex Benth. Journal of Planar Chromatography.2015; 28(3): 256–261. IF: 1.088
73. Kumar D*,Bhat ZA. Apigenin 7-glucoside from Stachys tibetica Vatke and its effect on anxiety like behaviour in experimental animals. Phytomedicine2014; 21: 1010-1014. Elsevier.IF: 6.656
74. Arya V, Kumar D*, Gautam M.Phytopharmacological review on flowers: Source of inspiration for drug discovery. Biomedicine & Preventive Nutrition 2013; 4: 45-51.
75. Kumar V,Bhat ZA*, Kumar D. Animal models of anxiety: a comprehensive review. Journal of Pharmacological and Toxicological Methods2013; 68: 175-183. IF: 2.285.
76. Kumar D*,Bhat ZA*, KumarV, Raja WY, Shah MY. Anti-anxiety activity of Stachys tibetica Vatke. Chinese Journal of natural Medicine2013; 13(2): 240-249. IF: 3.887
77. Kumar D,Bhat ZA*, KumarV, Shah MY. Coumarins from Angelica archangelica linn. and their effects on anxiety-like behaviour. Progress in Neuro- Psychopharmacology & Biological Psychiatry2013; 40:180–186. Elsevier, IF: 5.201
78. Kumar D, Bhujbal SS. Inhibitory effect of Ailanthus Excelsa Roxb. on ovalbumin-Induced airway inflammation and arachidonic acid induced inflammation in a murine model of asthma. Respirology 2013 Apr 1 (Vol. 18, Pp. 14-14). 111 River St, Hoboken 07030-5774, Nj Usa: Wiley-Blackwell. IF: 6.157
79. Kumar D,Bhat ZA*, Shah MY. Anti-anxiety activity of successive extracts of Angelica archangelica linn. on T- maze and forced swim test in rats. Journal of traditional Chinese medicines2012; 32(3): 423-429. IF: 2.547
80. Kumar D*,Bhat ZA*, KumarV,Chashoo IA,Khan NA, Shah MY. Chemical identification and in-vitro anti-inflammatory activity of Stachys tibetica oil by GC-MS and HRBC membrane stabilization method. Chemistry of natural compounds .2012: 48(5): 893-895. IF: 0.830.
81. Kumar D*, Arya V, Bhat ZA, Khan NA, Pradsad DN. The genus Crataegus (Rosaceae): chemical and pharmacological perspectives. Brazilian Journal of Pharmacognosy 2012; 22(5): 1187-1200. IF: 2.464
82. Kumar D,Bhat ZA*, Shah MY. Effect of successive extracts of Stachys tibetica Vatke (Lamiaceae) in anxiety. Oriental Pharmacy and Experimental Medicine 2012; 2012; 12: 247-53.
83. Kumar D,Bhat ZA*. Anti-anxiety activity of methanolic extracts of different parts of Angelica archangelica Linn. Journal of Traditional Complimentary Medicines2012; 2(3): 235-241. IF: 4.221
84. Chashoo IA, Kumar D, Bhat ZA*, Khan NA, Kumar V, Nowshehri JA. Antimicrobial studies of Sambucus wightiana Wall. ex. Wight & Arn. Journal of Pharmacy Research 2012; 5(5): 2467-2468.
85. Kumar V, Bhat ZA*, Kumar D, Khan NA, Chashoo IA. Evaluation of anti-inflammatory potential of leaf extracts of Skimmia anquetilia. Asian Pacific Journal of Tropical Biomedicine 2012; 1-4. IF: 1.514.
86. Kumar D*, Bhat ZA. Anxiolytic activity of aqueous extract of Angelica archangelica Linn. Inventi Rapid: Ethnopharmacology 2012; 2.http://www.inventi.in/Article/pep/596/12.aspx
87. Kumar D, Bhat ZA*, Kumar V, Chashoo IA, Khan NA, Ara I, Shah MY. Preliminary pharmacognostical and phytochemical evaluation of Stachys tibetica Vatke. TANG: International Journal of Genuine Traditional Medicine 2012; 2(1): e10, 1-7.
88. Kumar V, Bhat ZA, Kumar D, Khan NA, Chashoo IA, Ara I. Gastroprotective effect of leaf extracts of Basella alba against experimental gastric ulcers in rats. Brazilian Journal of Pharmacognosy 2012; 22(3): 657-662. IF: 2.464
89. Kumar D, Bhat ZA*, Kumar V, Khan NA, Chashoo IA. Zargar MI, Shah MY. Effects of Stachys tibetica essential oil in anxiety. European Journal of Integrative Medicines 2012; 4: e169-e176. IF: 1.813
90. Kumar D*, Arya V, Kaur R, Bhat ZA, Gupta VK, Kumar V. A review for immunomodulators in the Indian traditional health care system. Journal of Microbiology, Immunology and Infection 2012; 45: 165-184. IF: 10.273.
91. Kumar V, Bhat ZA, Kumar D, Shah MY, Chashoo IA, Khan NA. Anti-inflammatory activity of Petals of Crocus sativus ‘Cashmerianus’. International Journal of Phytopharmacology 2012; 3(1): 1-5. IF: 1.02.
92. Kumar V, Bhat ZA, Kumar D, Khan NA, Chashoo IA, Shah MY. Pharmacological profile of Crocus sativus -a comprehensive review. Pharmacologyonline 2011; 3: 799-811.
93. Kumar V, Bhat ZA, Kumar D, Chashoo IA, Khan NA. Anti-inflammatory activity of Basella alba Linn. Journal Pharmacy Education Research 2011: 2(1-2): 107-110.
94. Kumar D*, Bhat ZA, Kumar V, Zargar MI. A Short Review on Artemisia maritima Linn. International Journal of Research in Phytochemistry and Pharmacology 2011; 1(4): 201-206.
95. Deoda RS, Kumar D, Kadam PV, Yadav KN, Bhujbal SS, Patil MJ. Pharmacognostic and Biological studies of the roots of Rubia cordifolia Linn. (Rubiaceae). Int J Drug Dev & Res.2011: 3(3): 148-158. IF: 1.95
96. Sharma N, Agarwal G, Rana AC, Bhat ZA, Kumar D*. Transdermal drug delivery system: A tool of drug delivery. Int J Drug Dev & Res.2011; 3(3): 70-84. IF: 1.95
97. Kumar D*, Bhat ZA, Kumar V, Chashoo IA, Khan NA, Shah MY. Pharmacognostical and phytochemical evaluation of Angelica Archangelica Linn. Int J Drug Dev & Res.2011; 3(3): 173-188. IF: 1.95
98. Kumar D*, Mudgade SC, Bhat ZA, Bhujbal SS, Rub R. Antiallergic and anti-inflammatory effects of the fruits of Randia dumetorum lamk. Oriental Pharmacy and Experimental Medicine 2011; 11:161-167.
99. Kumar D*, Bhat ZA, Kumar V, Shah MY. Nature: Anxiolytics in the lap of nature. Webmed Central Pharmaceutical Sciences2011; 2(9): WMC002140.
100. Kumar D*, Deoda RS, Bhujbal SS, Singh P, Bhat ZA. Antihistaminic activity of aqueous extract of stem bark of Ailanthus excelsa Roxb. Pharmacognosy Research2011; 3(3): 220-224.
101. Kumar V, Bhat ZA, Kumar D,Bohra P, Sheela S. In-vitro anti-inflammatory activity of leaf extracts of Basella alba Linn. Int J Drug Dev & Res.2011; 3(2): 176-179. IF: 1.95
102. Kumar V, Bhat ZA, Kumar D,Shah MY, Chashoo IA, Khan NA. Physicochemical and Preliminary Phytochemical Studies on Petals of Crocus sativus ‘Cashmerianus’. Pharmacognosy Journal2011; 3(23): 46-49.
103. Bulani V*, Biyani K, Kale R, Joshi U, Charhate K, Kumar D, Pagor R. Inhibitory effect of Calotropis gigantea extract on Ovalbumin-induced airway inflammation and Arachidonic acid induced inflammation in a murine model of asthma Int J Drug Dev & Res.2011; 1(2): 19-25. IF: 1.95
104. Ahmed A, Shah WA, Akbar S, Kumar D, Kumar V, Younis M. In-vitro anti-inflammatory activity of Salix caprea Linn. (goat willow) by HRBC membrane stabilization method. Journal of Pharmacy Research 2011; 4(4): 1067-1068.
105. Kumar D*, Bhat ZA, Singh P, Khatanglakar V, Bhujbal SS. Antiasthmatic and antiallergic potential of methanolic extract of leaves of Ailanthus excelsa Roxb. Revista Brasileira de Farmacognosia2011; 21(1): 139-145. IF: 2.264
106. Bulani VD*, Ghaisas MM, Kumar D, Sarda AP, Bhamre SS. Anti-anaphylactic and Mast Cell Stabilizing Effect of Calotropis gigantea extract. Latin American journal of Pharmacy 2011; 30 (2): 363-7. IF: 0.240
107. Bhat ZA, Kumar D*, Shah MY. Angelica archangelica Linn.  is Angal on earth for the treatment of diseases: International Journal of Nutrition, Pharmacology, Neurological Diseases 2011; 1(1): 35-49.
108. Deoda RS*, Kumar D, Bhujbal SS. Gastroprotective effect of Rubia cordifolia linn. on aspirin plus pylorus ligated ulcer. Evidence-based Complementary and Alternative Medicine 2011: 5. doi:10.1155/2011/541624. IF: 2.165
109. Kumar D*,Buge PV, Bhat ZA, Dhumal JS, Katare YS, Bhujbal SS. Macroscopical and microscopical evaluation of Leaves of Clerodendrum inerme Gaertn. International Journal of Biological and Medical Research2011; 2(1): 404-408.
110. Ahmed A, Shah WA, Akbar S, Younis M, Kumar D*. A short chemical review on Salix Caprea commonly Known as Goat willow. International Journal of Research in Phytochemistry and Pharmacology2011; 1(1): 1-6.
111. Khan NA, Kumar D*, Bhat ZA, Kumar V, Nagpal N, Bhujbal SS. In vitro H1- Receptor antagonist activity of methanolic extract of tuber of Stephania glabra Vern. Bangladesh Journal of Pharmacology 2010; 5: 89-91.
112. Bhujbal SS*, Nanda RK, Deoda RS, Kumar D, Kewatkar SM, More LS, Patil MJ. Structure elucidation of a newly isolated saponin from Clerodendrum serratum (L) Moon. Oriental Pharmacy and Experimental Medicine 2010; 10(4): 319-321. Springer Link
113. Bhujbal S*, Nanda RK, Deoda R, Kumar D, Kewatkar SM, More LS, Patil MJ. Structure Elucidation of a Flavonoid Glycoside from the Roots of Clerodendrum serratum (L) Moon. Revista Brasileira de Farmacognosia2010; 20(6): 1001-1002. Sci Finder, IF: 0.676.
114. Kumar D*, Bhat ZA, Singh P, Bhujbal SS, Mudgade SC, Deoda RS. Antiallergic and anti-inflammatory Properties of methanolic extract of stem bark of Ailanthus excelsa Roxb. Latin American journal of Pharmacy 2010; 29(8): 1289-95. IF: 0.323.
115. Bhat ZA, Ali M, Ansari SH, Kumar D, Khan NA, Singh P, Chashoo IA. Two disaccharides namely Glucopyranosyl-O-(1®4) fructofuranoside (Sucrose) and Glucopyranosyl-O-(1®4) glucopyranoside (Maltose) from Aralia cachemirica Decne. International Journal of Biological and Medical Research2010;1(4): 295-297.
116. Nagpal N, Manisha A, Sandeep R, Gaurav S, Sharma D, Kapoor R. Muco-adhesion Based Solid Dosage Form: The Next Generation. Research Journal of Pharmaceutical Dosage Forms and Technology 2010; 2(5): 206-214.
117. Kumar D*,Bhat ZA, Singh P, Mudgade SC, Bulani VD, Bhujbal SS. Anti-allergic and anticataleptic activity of aqueous extract of leaves of Ailanthus excelsa Roxb.International Journal of Pharmaceutical Sciences and Research2010; 1(9): 45-51. Elsevier.
118. Pareek V, Singh M, Bhat ZA, Singh P, Kumar D, Sheela S. Studies on mucilage of Basella alba Linn. Journal of Pharmacy Research 2010; 3(8): 1892-1894.
119. Kumar D*,Bhat ZA, Singh P, Shah MY, Bhujbal SS. Ailanthus excelsa Roxb. is Really A Plant of Heaven. International Journal of Pharmacology2010; 6(5): 535-550. Science alert, IF: 1.503.
120. Bhujbal SS, Kumar D, Deoda RS, Kewatkar SM, Patil MJ. In-Vitro and In-Vivo Antiasthmatic studies of Clerodendrum serratum Linn in Guinea Pigs. International Journal of Pharmaceutical Research and Development 2010; 2: 4(2): 1-6.
121. Kumar D*,Bhat ZA, Singh P, Shah MY, Bhujbal SS. Macro and Microscopical evaluation of Trunk bark of Ailanthus excelsa Roxb. Pharmacognosy Journal 2010; 2(9): 278-284. Elsevier.
122. Kumar D*,Bhujbal SS, Deoda RS, Mudgade SC. Bronchodilator Activity of Aqueous Extract of Stem Bark of Ailanthus excelsa Roxb. Pharmacognosy Research2010; 2(2): 102-106. Pubmed.
123. Kumar D*,Bhujbal SS, Patil PS, Buge PV. In-Vitro and In-Vivo Activities of Stem Bark of Methanolic Extract of Ailanthus excelsa Roxb. In The Management of Asthma. International journal of pharmacology2010; 6(3): 284-289. Science alert, IF: 1.503.
124. Dinesh K, Bhujbal SS, Patil PS, Buge PV. In vitro and in vivo activities of stem bark of methanolic extract of Ailanthus excelsa Roxb. in the management of asthma. IJP-International Journal of Pharmacology. 2010;6(3):284-9.
125. Kumar D*, Bhujbal SS, Deoda RS, Mudgade SC. In-vitro and In-vivo Antiasthmatic Studies of Ailanthus excelsa Roxb. on Guinea Pigs. Journal of Scientific Research2010; 2(1), 196-202. PubMed.
126. Kumar D, Prasad DN, Parkash J, Bhatnagar SP, Kumar D*. Antiasthmatic Activity of Ethanolic Extract of Aerva lanata Linn. Pharmacologyonline 2009; 2: 1075-1081.
127. Bhujbal SS*, KewatkarSM, Kumar D, Mudgade SC, Patil MJ. In Vivo and In Vitro Antiasthmatic Studies of Clerodendrum serratum Linn. Newsletter. Pharmacologyonline 2009; 2: 745-752.
128. Bhujbal SS*, Kumar D,Deoda RS, Deore TK, Patil MJ.  Antiasthmatic activity of roots of Hemidesmus indicus R.Br. Pharmacologyonline 2009; 1: 209-216.

Book chapters

1. Kumar D & SK Vats, Chapter 9: Crataegus rhipidophylla, 2017, Medicinal & Nutraceutical Plants from The Himalayas, India, Vol. I, New India Publisher.
2. Lal B & Kumar D, Chapter 5: Dactylorhiza hatagirea (D. Don), 2017, Medicinal & Nutraceutical Plants from The Himalayas, India, Vol. I, New India, Publisher
3. Sharma R, Rana A, Kumar D*, Chemical diversity among different parts of Camellia sinensis and their bio-functional potentials, 2020, Bioprospecting of waste from Agro-processing industries, India, Vol. I, Springer Nature Group.
4. Sharma S, Kumar D*. Chemical Composition and Biological Uses of Crocus sativus L (Saffron). 2021. InEdible Plants in Health and Diseases, Singapore. PP. 249-277; DOI:10.1007/978-981-16-4959-2_7, Springer.
5. Kumar D, Bhat ZA, Chashoo IA, Deoda RS, Mudgade SC, Kumar V. Bronchodilator activity in traditional medicines: gift of god kingdom. Bronchitis. 2011 Aug 23;171.

Publications (2022-2023)

1.  Bhattacharyya P, Kumar S, Lalthafamkimi L, Sharma R, Kumar D, Singh D, Kumar S. Molecular and phytomedicinal stability of long term micropropagated Malaxis acuminata: An endangered terrestrial orchid of biopharmaceutical importance. South African Journal of Botany. 2023 Apr 1;155: 372-382. IF: 3.31
2.  Kumar R, Kumar D*. Comprehensive metabolomics and antioxidant activity of Allium species viz Allium semenovii, A. sativum and A. cepa: an important spice. Food Research International. 2023: 112584. IF: 7.425.
3. Walia S, Kumar P, Kumar D*, Kumar R*. A preliminary study on suitability of growing ginseng (Panax ginseng Meyer) in the Western Himalayan region. Plant Soil Environ. 2023;69. IF: 2.328
4. Kumari V, Kumar D, Bhardwaj R, Kumar D*. Metabolome analysis, nutrient and antioxidant potential of aerial and underground parts of Ajuga parviflora Benth. Microchemical Journal. 2023: 108451. IF: 5.304
5. Sood A, Thakur K, Joshi R, Kumar D, Warghat AR. Comparative quantification of dactylorhin among different wild tissues and in vitro cultures of Dactylorhiza hatagirea (D. Don), an endangered medicinal orchid of Western Himalayas. South African Journal of Botany. 2023; 153: 172-7. IF: 3.31
6. Shakeya P, Thakur R, Sharan H, Yadav N, Kumar M, Chauhan R, Kumar D, Kumar A, Singh S, Singh S*. GE biplot and regression based multi-environment investigations for higher yield and essential oil content in German chamomile (Matricaria chamomilla L.). Industrial Crops & Products. 2023, 193: 116145. IF: 6.449
7. Kumar D, Kumari V, Kumar D*. Metabolite profiling, antidiabetic, and antioxidant potential of different tissues of Trillium govanianum Wall. ex D. Don. South African Journal of Botany. 2023: 23: 102-108. IF: 3.31
8. Rattan S, Kumar D*, Warghat AR. The influence of phenylalanine feeding on cell growth, antioxidant activity, phenylpropanoids content, and yield in cell suspension culture of Rhodiola imbricata (Edgew.). Plant Cell, Tissue and Organ Culture (PCTOC). 2022 Nov;151(2):347-59. IF: 2.726
9. Devi J, Kumar A, Kumar D, Bhushan S. Adventitious root cultures of Arnebia euchroma: A sustainable alternative for the production of natural pigments. Industrial Crops and Products. 2022 Nov 1;187: 115461. IF: 6.449
10. Kumari V, Joshi R, Chawla A, Kumar D*. Metabolome analysis of Dactylorhiza hatagirea (D. Don) Soo reveals a significant antioxidant and nutritional potential of its tubers. South African Journal of Botany. 2022 Nov 1; 150:431-442. IF:3.31
11. Partap M, Rattan S, Kumar D*, Warghat AR. Bioprocess development for enhancing cell biomass, differential picrosides accumulation, and gene expression profiling at shake flask levels in suspension cultures of Picrorhiza kurroa. Industrial Crops and Products. 2022 Nov 1;187: 115311. IF: 6.449
12. Bhattacharyya P, Lalthafamkimi L, Sharma T, Kumar D, Kumar A, Kumar S. Metabolic and tissue-specific expression profiling in micropropagated plants of Malaxis acuminata: An endangered medicinal orchid. Plant Cell, Tissue and Organ Culture (PCTOC). 2022 Oct 7:1-5. IF: 2.726
13. Yadav N, Shakya P, Kumar A, Gautam RD, Chauhan R, Kumar D, Kumar A, Singh S, Singh S. Investigation on pollination approaches, reproductive biology and essential oil variation during floral development in German chamomile (Matricaria chamomilla L.). Scientific Reports. 2022;12(1):1-3. IF: 4.996
14. Partap M, Kumar P, Kumar P, Kumar D*, Warghat AR. Growth kinetics, metabolites production and expression profiling of picrosides biosynthetic pathway genes in friable callus culture of Picrorhiza kurroa Royle ex Benth. Applied Biochemistry and Biotechnology. 2020 Dec;192(4):1298-317. IF: 3.094
15. Sharma R, Kumar D*. Polyphenol Encapsulates from the Waste Biomass of C. sinensis and Their Simulated Oral, Gastric, and Intestinal Stability Studies: Nutraceutical Application. ACS Food Sci. Technol. 2022, 2, 8, 1257–1265. IF:
16. Kumari A, Kumar D*, Gulati A, Maurya SK. Mechanistic studies on polyphenol rich fractions of Kangra tea by HPTLC and NMR for their antioxidant activities. Journal of Food Science and Technology. 2022:59 (7): 2751-2763. IF: 3.117
17. Kaundal R, Kumar M, Kumar S, Singh D, Kumar D*. Polyphenolic Profiling, Antioxidant, and Antimicrobial Activities Revealed the Quality and Adaptive Behavior of Viola Species, a Dietary Spice in the Himalayas. Molecules. 2022 Jan;27(12): 3867. IF: 4.927
18. Partap M, Chhimwal J, Kumar P, Kumar D*, Padwad Y, Warghat AR. Growth dynamics and differential accumulation of picrosides and its precursor metabolites in callus cell lines of Picrorhiza kurroa with distinct anti-steatotic potential. Process Biochemistry. 2022 Jun 6. IF: 4.885
19. Sinha K, Kumar S, Rawat B, Singh R, Purohit R, Kumar D*, Padwad Y. Kutkin, Iridoid glycosides enriched fraction of Picrorrhiza kurroa promotes insulin sensitivity and enhances glucose uptake by activating PI3K/Akt signaling in 3T3-L1 adipocytes. Phytomedicine. 2022 May 25:154204. IF: 6.656
20. Partap M, Kumar P, Kumar P, Pal PK, Kumar D, Warghat AR, Kumar S. Fruit derived callus and cell suspension culture as promising alternative sources for mogrosides production in Siraitia grosvenorii (Swingle) C. Jeffrey: a zero-caloric natural sweetener. Journal of Food Composition and Analysis. 2022 May 1; 108: 104450. IF: 4.52
21. Joshi R, Sharma S, Kumar D*. Advances of Ion Mobility Platform for Plant Metabolomics. Critical Reviews in Analytical Chemistry. 2022 Apr 26:1-7. IF: 5.686
22. Kumar A, Joshi R, Vasishth A, Guleria V, Kumar D*. UHPLC-QTOF-IMS-Based Metabolite Fingerprinting of Underutilized Cordia myxa Fruits and Leaves: A Nutraceutical Source. ACS Food Science & Technology. 2022 Apr 20;2(5):793-807. IF:
23. Sharma A, Tirpude NV, Bhardwaj N, Kumar D, Padwad Y. Berberis lycium fruit extract and its phytoconstituents berberine and rutin mitigate collagen–CFA-induced arthritis (CIA) via improving GSK3β/STAT/Akt/MAPKs/NF-κB signaling axis mediated oxi-inflammation and joint articular damage in murine model. Inflammopharmacology. 2022 Apr;30(2):655-66. IF: 5.093

Ph. D Research Scholar

Miss Shruti Sharma

Project Fellow

Miss Krishna Thakur

 Prospective Team Members 

 Postdoctorate  and Ph.D positions are available for self-motivated persons.